Electromed

Electromed-Electrospun Biomimetic Nanofibres as Regenerative Medicines

With support from the Danish Strategical Research Council, the strategic research project, Electromed was launched in January 2012. This four year and five month project, 1 January 2012 till 31 May 2016, is administrated by Aarhus University.

Summary

Based on our unique strengths in interdisciplinary nanoscience and nanotechnology at iNANO, and in collaboration with several top international leaders and laboratories in electrospinning, biomaterials, drug delivery and tissue regeneration, we are proposing to develop novel electrospun biomimetic nanofibres as regenerative medicines that we call “ElectroMed”. This ElectroMed will integrate the nanostructure and the biological cues that are needed to stimulate tissue regeneration in two dimensions for pelvic floor tissue, and in three dimensions, for nerve tissues.  In essence, the ElectroMed combines a physical, nano-fibrous scaffold having the appropriate topography, and delivers the signalling molecules and healing drugs (e.g., various growth factors, bioactive agents and anti-inflammatory drugs) that can stimulate and control the regeneration of injured or diseased tissues. The design model for the overall fibrillar and porous nanostructure and bio-function of the ElectroMed will be the extracellular matrix, or ECM. Electrospinning, one of the most exciting nanotechnology innovations in recent years, is a robust, straightforward, and powerful method to produce nanofibers with different topographies and with the potential to incorporate drugs during processing, or combining physical/chemical methods with ease. Another feature of the ElectroMed is the use of stimuli-responsive, or “smart” polymer components, e.g., that are responsive to certain key environmental factors, such as temperature and pH, to allow stimuli-responsive control release of the bioactives. In summary, our proposed ElectroMed applies the powerful technique of electrospinning to fabricate a biomimetic, drug-loaded nanofibers from degradable polymers in a simple, rapid, and reproducible process.

Participating parties

iNANO, Aarhus University

Ringgaden 1

8000 Århus C

Denmark

Contribution to the project:

  • General scientific knowledge in the nanoscience field and nanomaterials design
  • Specific scientific knowledge in chemistry and drug release.
  • Scientific knowledge in the development of nanofibres.
  • Scientific knowledge of state-of-the-art surface analytical and microscopy techniques.

General areas of expertise:

  • The fully equipped Electrospinning laboratory at iNANO has single/coaxial nozzle electrospinner systems, expertise in advanced nanomaterials analysis including XPS, ToF-SIMS, SEM, TEM, AFM, XRD, and FTIR.
  • Expertise in the design of new surface and nanofibre technologies. In the past four years iNANO has successfully carried out the Nanononwovens project (funded by the Danish Advanced Technology Foundation) using the electrospinning technique, which led to the direct scientific output of more than 20 peer-reviewed publications and the development of commercial nanononwoven filtration textiles from the industry partner Fibertex.
  • iNANO is a leading Centre for Nanotechnology in Europe consisting of 65 fulltime academic staff in the fields of chemistry, physics, molecular biology, biology, and medicine.
  • EU partners in Germany, UK, Italy, Switzerland.
  • International partners in USA, Australia, and China

 

Flemming Besenbacher, Prof., dr. scient (fbe@inano.au.dk)

Menglin Chen, Postdoc, PhD (menglin@inano.au.dk)

Ken Howard, Assoc. Prof. PhD (kenh@inano.au.dk)

Jens V. Nygaard, Assoc. Prof. PhD (jvn@iha.dk) Aarhus School of Engineering

 

 

Aarhus University Hospital

Brendstrupgaardsvej

8200 Århus N

Denmark

Contribution to the project:

  • Specialist in Obstetrics and Gynaecology
  • Scientific knowledge in Urogynaecological Clinic
  • Specific scientific knowledge on the stem cell therapy
  • Scientific knowledge on the vascularization
  • Specific scientific knowledge on the growth factor
  • Expertise on animal study

General areas of expertise:

  • Leading expertise in Urogynaecological Clinic
  • Leading expertise in vascular surgery and orthopaedic research.
  • Full equipped Animal Experimental laboratory, including Stable and observation facilities for full characterisation of tissue engineering scaffolds
  • International partners in USA, France, Germany and more

Susanne Maigaard Axelsen, Prof. (susanne.axelsen@skejby.rm.dk) Head of Department of Gynaecology and Obstetrics

John Michael Hasemkam, Prof. (hasenkam@sun.au.dk)

 

 

National University of Singapore

21 Lower Kent Ridge Road

Singapore 119077

Contribution to the project:

  • Specific scientific knowledge on electrospinning
  • Scientific knowledge on the in vitro and in vivo study of nerve conduits.

General areas of expertise:

  • Known globally for pioneering work on electrospinning for regeneration of tissues, harvesting of sunlight, and treatment of water
  • Full equipped electrospinning laboratory
  • Several national and international partners from both academia and industry.
  • International partners in Australia, USA, India, China

Seeram Ramakrishna, Prof. (seeram@nus.edu.sg)

Molamma P. Prabhakaran (nnimpp@nus.edu.sg)




Chinese Academy of Science

Beijing

China

Contribution to the project:

  • Specific scientific knowledge on Nanotoxicology
  • Scientific knowledge on synthesis and behaviour of nanomedicine.
  • Scientific knowledge on cellular uptake and intracellular trafficking of nanomaterials.
  • Scientific knowledge on in vivo fate and biodistribution of nanomaterials, and tissue and cellular targeting for cancer treatment.
  • Expertise in animal study

 

General areas of expertise:

  • Expertise in safety evaluation of nanomaterials.
  • Expertise in effects of anti-adhesive electrospun sheets on postoperative adhesions by rat and porcine intra-abdominal adhesion model.
  • Expertise in advanced nanomaterials analysis including XPS, ToF-SIMS, SEM, TEM, AFM, XRD, and FTIR.
  • The CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety currently counts 40 fulltime academic staff, and 60 PhD-students.
  • Several national and international partners from both academia and industry.
  • The fully equipped biology laboratory at KLNN has Confocal, flow cytometry, ESEM, small animal Imaging systems, and animal/tissue exposure systems.
  • International partner in EU FP7 nanosafety project (MARINA 2011-2014, Prof. Chen)

Yuliang Zhao, director, Prof. PhD (zhaoyuliang@ihep.ac.cn)

Chunying Chen, Prof. PhD (chenchy@nanoctr.cn)

 

 

 

Coloplast A/S

Holtedam 1,Dageløkke

3050 Humlebæk

Denmark

Contribution to the project:

  • Practical utilisation of nanotechnology research in commercial pelvic floor prolapse care.
  • In vitro cell laboratories and competences.

General expertise:

  • Ostomy and urology care as well as wound and skin care specialists and state of the art production technology.
  • Market leader in intimate health care, with extensive international knowledge of the global market.
  • World class general product development skills, knowledge and competencies, related to medical devises.

Pia Nielsen, Project Manage of biomaterial, Global R&D, Coloplast (dkpin@coloplast.com)

 

 

Department of Bioengineering

University of Washington, USA (UW)

Contribution to the project:

  • Specific scientific experience with polymeric biomaterials, surface functional modification, drug incorporation and delivery, nanocarriers
  • Scientific knowledge of synthesis and behavior of stimuli-responsive, or “smart” polymers; principles and practice of drug delivery; preparation of functionalized surface coatings.

General areas of expertise:

  • Teaching and student research supervision experience
  • Consultant to academia and industry for over 50 yrs.
  • Member, Scientific Advisory Board, Inst of Bioeng and Nanotechnology (IBN), Singapore, 2009-present
  • Distinguished Professor, Kyungpook Natl Univ Medical School, Daegu, So. Korea, 2008-2013
  • Co-founder of two biotechnology companies; ongoing at present

Allan Hoffman, Prof. (hoffman@u.washington.edu) University of Washington, USA

Honorary Prof. University of Aarhus, Denmark

Member of National Academy of Engineering, USA

Project Management Structure