PAPER: Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
Dimethyl fumarate is used in the treatment of psoriasis and multiple sclerosis although it's mechanism of action is still unknown. Now, the crystal structure of dimethyl fumarate has been published in Nature Communications.
In collaboration with researchers from the Department of Molecular Biology and Genetics, Professor Kurt Gothelf has recently published results explaining the elusive mechanism of action of dimethyl fumarate.