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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Associate Professor Rikke Louise Meyer and Postdoc Chengfang Pang receives VILLUM Experiment grants. Image: VILLUM FONDEN

2019.09.10 | iNano

VILLUM FONDEN awards DKK 4 million for bold experiments at Interdisciplinary Nanoscience Center

Congratulations to Associate Professor Rikke Louise Meyer (iNANO) for receiving a Villum Experiment grant. Also Postdoc Chengfang Pang has been awarded approx. DKK 2 million to carry out research at iNANO.

The four molecular biologists behind the spin-out company omiics (from left): Yan Yan, Morten Venø, Junyi Su and Susanne Venø (photo: Kenneth Frydensbjerg)

2019.09.09 | iNano

Molecular biologists are successful with spin-out company

Four molecular biologists from Aarhus University have started a spin-out company that offers to identify very small differences between biological samples with a special technique. The researchers build on the experience they gained when they were students and postdocs at the Department of Molecular Biology and Genetics/iNANO with a special…

CADIAC publishes in Journal of the American Chemical Society on a novel approach to isotopically labeled beta-amino acid /beta-aminoketone fragments. Image: Reprinted and modified with permission from J. Am. Chem. Soc.20191413011821-11826. Copyright 2019 American Chemical Society.

2019.09.05 | iNano

New synthetic technique for carbon isotope labeling

CADIAC publishes in Journal of the American Chemical Society where they report on a novel method for the introduction of carbon isotopes into pharmaceutical relevant molecules.

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