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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Post docs Line D. F. Nielsen and Malthe Hansen-Bruhn after they received the first price for their 3-minute pitch at the TTRN 7th conference. (Photo by Gothelf Lab)

2019.06.06 | iNano

Post docs from the Gothelf Lab win pitch competition

Line Debois F. Nielsen and Malthe Hansen-Bruhn attended the Transatlantic Telehealth Research Network's (TTRN)'s 7th conference at Technical University of Denmark (DTU) and won first price.

At the CytoPad centre, researchers will use advanced immunization techniques to produce antibodies from mice and llamas. Click on the graphic to see it full size. Graphic: Daniel Otzen

2019.05.28 | iNano

DKK 10 million for research into Parkinson's disease

Professor Daniel Otzen from the Interdisciplinary Nanoscience Center (iNANO) at Aarhus University has received DKK 10 million from the Lundbeck Foundation to develop new and better methods to diagnose and prevent Parkinson's disease, among other things using antibodies from llamas.

iNANO PhD student Heba Khateb receives Organic & Biomolecular Chemistry Prize at International Symposium on Suprabiomolecular Systems (SupraBio 2019) in Barcelona on 15-17 May 2019. Photo by courtesy of Heba Khateb.
Heba Khateb is PhD student in Centre for Cellular Signal Patterns (CellPAT), a Centre of Excellence headed by Professor Jørgen Kjems.

2019.05.22 | iNano

The Royal Society of Chemistry prize for iNANO researcher

Congratulations to PhD student Heba Khateb who has received the Organic & Biomolecular Chemistry Prize for her poster presentation at International Symposium on Suprabiomolecular Systems (SupraBio 2019).

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