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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

The four molecular biologists behind the spin-out company omiics (from left): Yan Yan, Morten Venø, Junyi Su and Susanne Venø (photo: Kenneth Frydensbjerg)

2019.09.09 | iNano

Molecular biologists are successful with spin-out company

Four molecular biologists from Aarhus University have started a spin-out company that offers to identify very small differences between biological samples with a special technique. The researchers build on the experience they gained when they were students and postdocs at the Department of Molecular Biology and Genetics/iNANO with a special…

CADIAC publishes in Journal of the American Chemical Society on a novel approach to isotopically labeled beta-amino acid /beta-aminoketone fragments. Image: Reprinted and modified with permission from J. Am. Chem. Soc.20191413011821-11826. Copyright 2019 American Chemical Society.

2019.09.05 | iNano

New synthetic technique for carbon isotope labeling

CADIAC publishes in Journal of the American Chemical Society where they report on a novel method for the introduction of carbon isotopes into pharmaceutical relevant molecules.

Associate Professor Rikke Louise Meyer receives ST Industrial Collaboration Award 2019. (Photo: Lars Kruse, AU Photo)

2019.08.26 | iNano

ST Award goes to iNANO researcher

Congratulations to Associate Professor Rikke Louise Meyer (iNANO and Dept. of Bioscience) who has received this year's Industrial Collaboration Award given by Science and Technology, Aarhus University's faculty of science and technology.

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