Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
M
H 1592, 224
P +4587156741
P +4520725238
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

iNANO researchers receive funding for research infrastructure from the Carlsberg Foundation. (Photo: Lise Balsby, AU Photo)
Grant recipients: Ken Howard (Photo: Maria Randima, AU Foto), Jørgen Kjems (Photo: Jesper Rais, AU Foto), Jeppe Vang Lauritsen (Photo: Lars Kruse, AU Foto), Nina Lock (Photo: Maria Randima, AU Foto), Henrik Birkedal (Photo: Lise Balsby, AU Foto), Marianne Glasius (Photo: Jesper Rais, AU Foto).

2018.12.11 | iNano

New funding for research infrastructure

The Carlsberg Foundation has awarded DKK 4.460.000 in total for research infrastructure for iNANO researchers. This new equipment will be used for research in circular RNA, functional materials, immunotherapy and much more.

Brainnovation Day 2018 at iNANO. Associate Professor Jørgen Skibsted presents the next speaker, Christer Forsgren from STENA Metall Group. (Photo: Lise R. L. Pedersen)

2018.12.07 | iNano

Brainnovation Day increases dialogue and cooperation with industry

On November 29, 2018, the Interdisciplinary Nanoscience Center (iNANO), together with the Center for Integrated Materials (iMAT), once again invited the industry to Brainnovation Day. This year, the aim was to address the challenges encountered by industry in the degradation and recycling of inorganic materials.

Professor Jan Skov Pedersen will host the 16th Nordic Workshop on Scattering from Soft Matter in January 2019. (Illustration by Jeppe Lyngsø: RipAn structure from Small-angle X-ray Scattering study)

2018.12.06 | iNano

The 16th Nordic Workshop on Scattering from Soft Matter is hosted by Professor Jan Skov Pedersen

The leading Nordic researchers within the field of soft matter studied by scattering methods will meet in Aarhus on 9th-10th of January. Deadline for registration is December 2018.

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