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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Nina Lock and Troels Skrydstrup each lead their research group, but collaborate on a common task: to develop sustainable catalysts that can transform CO2 into valuable resources. Photo: Dorthe Lundh

2019.06.14 | iNano

CO2 could replace fossil fuels in industry

Researchers at Aarhus University are developing new chemical technologies to reduce CO2 emissions and support the green transition in both public and private manufacturing companies.

Post docs Line D. F. Nielsen and Malthe Hansen-Bruhn after they received the first price for their 3-minute pitch at the TTRN 7th conference. (Photo by Gothelf Lab)

2019.06.06 | iNano

Post docs from the Gothelf Lab win pitch competition

Line Debois F. Nielsen and Malthe Hansen-Bruhn attended the Transatlantic Telehealth Research Network's (TTRN)'s 7th conference at Technical University of Denmark (DTU) and won first price.

At the CytoPad centre, researchers will use advanced immunization techniques to produce antibodies from mice and llamas. Click on the graphic to see it full size. Graphic: Daniel Otzen

2019.05.28 | iNano

DKK 10 million for research into Parkinson's disease

Professor Daniel Otzen from the Interdisciplinary Nanoscience Center (iNANO) at Aarhus University has received DKK 10 million from the Lundbeck Foundation to develop new and better methods to diagnose and prevent Parkinson's disease, among other things using antibodies from llamas.

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