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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Collaboration between Novo Nordisk and Professor Kurt Gothelf’s laboratory at Aarhus University yields novel method to engineer large multi-antibody-like nanostructures using DNA nanotechnology. Assembly of an artificial IgM from a DNA-antibody conjugate and a small 5-way DNA structure. The structure is characterized by Transmission Electron Microscopy (100 x 100 nm). Graphics by Thorbjørn B. Nielsen and Kurt Gothelf with permission from Angewandte Chemie Int. Ed.

2019.05.10 | iNano

New efficient way to engineer nanostructures mimicking natural immune response complexes

Collaboration between Novo Nordisk and Professor Kurt Gothelf’s laboratory at Aarhus University yields novel method to engineer large multi-antibody-like nanostructures using DNA nanotechnology. The results demonstrate the potential for assembly of multiple proteins and also other materials to enhance properties of traditional therapies.

Poul Nissen (photo: Lisbeth Heilesen/AU)

2019.04.25 | iNano

Poul Nissen receives Euro 1.34 million to study the insulin receptor

The Novo Nordisk Foundation has awarded Professor Poul Nissen a five-year grant in the form of a so-called "NNF Distinguished Investigator 2019 grant" within "Bioscience and Basic Biomedicine", which is given to researchers who have shown their ability to carry out and lead research at the very highest international level.

Dr. Edit Brodszkij receives EU funding for research in cell mimicry. Private photo.

2019.04.25 | iNano

Dr. Edit Brodszkij receives EU funding for research in cell mimicry

iNANO researcher, Dr. Edit Brodszkij, receives Marie Sklodowska-Curie Individual Fellowship to design polymeric artificial organelles in Assoc. Prof. Brigitte Stadler's research group at iNANO.

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