Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
M
H 1592, 224
P +4587156741
P +4520725238
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

AU Researchers perform nanodissection using Atomic Force Microscopy (AFM) and unveil how cable bacteria conduct energy. The image shows micrograph (left) of filamentous Desulfobulbaceae and AFM topography (Right) og the outer membrane after nanodissection. Image: Mingdong Dong
The left column, bacterial cable under optical microscopy, which is hybridized with a specific ELF654 FISH and DAPI probe. The middle column, three kinds of cell junctions. The right column, AFM topography and Young’s modulus (logarithm) map of inside of outer membrane after nanodissection. The black dashed arrows indicate cell junction. The solid arrows indicate one string attaching at the inner face of outer membrane. Image: Mingdong Dong
Associate Professor Mingdong publish in Proceedings of the National Academy of Sciences (PNAS) on in vitro single-cell dissection of cable bacteria. Photo: Maria Randima (AU Photo)

2018.10.12 | iNano

Nanodissection unveils how bacteria conduct energy

Recent discoveries show that cable bacteria can function as electrical wires, however it is unclear how it is possible to have long-range electron transfer through these cobweb thin bacterial chains. Using Atomic Force Microscopy as a nanoscalpel AU researchers now bring us closer to understanding the interior structure of the bacteria.

Steffan K. Kristensen, Simon Laursen and Troels Skrydstrup publish in Angewandte Chemie Int. Ed. on a safer and more potent hydrothiolation using methanethiol. The studies are funded by BIOVALUE SPIR from the Innovation Fund Denmark, and the Danish National Research Foundation and Haldor Topsøe. (Photo: Aidan Esmaeli (Aidin Esmaeli Photography) and Lars Kruse (AU Photo))
New method for the hydrothiolation of π-systems with transition metal complexes. Click image to enlarge. (Image: Troels Skrydstrup)

2018.09.20 | iNano

Simpler and safer method for handling a useful but foul-smelling gas in chemical synthesis

Researchers at the Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, have developed both an ingenious, as well as a safe procedure for using the ’rotten egg’ smelling and flammable gas, methanethiol, in certain chemical reactions.

Associate Professor Henrik Birkedal develops biodegradable superglue inspired by nature’s solutions in blue mussels. (Photo: Lise Balsby, AU Photo)
Associate Professor Henrik Birkedal’s  innovative materials are inspired by the ability of blue mussels to stick to almost anything under water. (Photo: Colourbox.com)

2018.09.18 | iNano

Research inspired by nature’s technologies

Associate Professor Henrik Birkedal has been interviewed by Weekendavisen on the potential of biomimicry and his progress in developing an innovative biodegradable superglue.

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