Aarhus University Seal / Aarhus Universitets segl

Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  


Professor Birgit Schiøtt receives DKK 6.6 million for digital infrastructure platform. (Photo: Lars Kruse)

2019.01.31 | iNano

DKK 6.6 m for biomolecular simulations

Professor Birgit Schiøtt (Department of Chemistry and iNANO) has received DKK 6.6 million (EUR 0.9 million) to establish a digital infrastructure platform to make simulations of complex biological systems.

Professor Flemming Besenbacher, iNANO's founder, receives The Fortune Award for Circular Economy Leadership 2019. (Archive photo: Lars Kruse, AU Photo).

2019.01.23 | iNano

Professor Flemming Besenbacher receives distinguished honor

The Fortune Award for Circular Economy Leadership 2019 has been given to iNANO's founder Professor Flemming Besenbacher for his great commitment to promoting circular economy in Denmark and internationally.

AU researchers from Department of Chemistry and iNANO discover new methodology for localized delivery of antibacterial agents to the surface of metallic implants (Cover by Chemical Communications)
Associate Professors Alexander Zelikin and Rikke Louise Meyer collaborate on interdisciplinary findings combining the fields of biology and chemistry in localized synthesis of antibacterial drugs at metallic implants. (Photo: Lars Kruse, AU Foto)

2019.01.11 | iNano

Meyer and Zelikin laboratories featured on the cover of Chemical Communications

Interdisciplinary research by AU scientists combines the fields of chemistry and biology in fighting bacterial infections locally on metallic implants by exploiting a build-in feature. The work is highlighted on the cover of the journal ChemComm.

Showing results 22 to 24 of 226

Previous 1 2 3 4 5 6 7 8 9 10 Next

Recent publications

Sort by: Date | Author | Title