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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Troels Skrydstrup receives honorary professorship from Nanchang University (China). (Photo: Lars Kruse)

2018.12.14 | iNano

Honorary Professorship to Troels Skrydstrup from Nanchang University

On the 10th of December 2018, Professor Troels Skrydstrup received an honorary professorship from Nanchang University (China), which was delivered by the vice-president of the university, Professor Xiaohua Deng.

AU researchers from Department of Chemistry and iNANO develop new artificial enzyme-like nanoparticles with high potential in prodrug therapy. (Illustration: Lise Refstrup Linnebjerg Pedersen and Colourbox.com)
Associate Professors, Alexander Zelikin, Nina Lock and Rikke Louise Meyer have collaborated on expanding the so far narrow range of nanozymes greatly and with a novel scope of substrate. (Photo: Lars Kruse and Maria Randima, AU Foto)

2018.12.14 | iNano

AU researchers engineer enzyme-like nanoparticles with potential in prodrug therapy

Development of nanozymes constitutes an increasingly important mean to overcome the limitations of natural enzymes in biotechnology and biomedicine. AU researchers have just recently expanded the yet narrow range of nanozymes greatly and reveal a novel example of nanozyme‐prodrug‐therapy.

iNANO researchers receive funding for research infrastructure from the Carlsberg Foundation. (Photo: Lise Balsby, AU Photo)
Grant recipients: Ken Howard (Photo: Maria Randima, AU Foto), Jørgen Kjems (Photo: Jesper Rais, AU Foto), Jeppe Vang Lauritsen (Photo: Lars Kruse, AU Foto), Nina Lock (Photo: Maria Randima, AU Foto), Henrik Birkedal (Photo: Lise Balsby, AU Foto), Marianne Glasius (Photo: Jesper Rais, AU Foto).

2018.12.11 | iNano

New funding for research infrastructure

The Carlsberg Foundation has awarded DKK 4.460.000 in total for research infrastructure for iNANO researchers. This new equipment will be used for research in circular RNA, functional materials, immunotherapy and much more.

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