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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  


Dr. Hossein Mohammad-Beigi and Professor Daniel Otzen, Aarhus University,  shows that a specific and widely common strain of olives excels as a natural inhibitor of Parkinson’s disease progress. (Image: Colourbox.com)

2019.03.29 | iNano

Widely common olive species excel as natural inhibitor of Parkinson’s disease

The compositions of antioxidants in a certain species of olive fruits have been found to be superior in protection against Parkinson's disease. As Parkinson's disease is one of the most common neurodegenerative diseases, but still without a cure, this is an important finding on the way to combat this crippling condition.

Professor Daniel Otzen's group and collaborators publish in ACS Nano the impact of nanoparticle design on Parkinson's disease therapies. (Image: Colourbox)

2019.03.21 | iNano

Exploring the impact of nanoparticle design on Parkinson's disease therapies

AU researchers, Daniel Otzen, Hossein Mohammad-Beigi, and Cagla Sahin and collaborators publish in ACS Nano on how the design of nanoparticles have a crucial role in the inhibition of alpha-synuclein fibrillation and the progress of Parkinson’s Disease, accordingly.

Associate Professors Alexander Zelikin and his research team publish in Advanced Science on macromolecular prodrugs based on marketed antiviral nucleoside analogues. (Photo: Lars Kruse, AU Foto)

2019.03.07 | iNano

Zelikin laboratories publish in Advanced Science on nature‐inspired scaffold for macromolecular prodrugs

Researchers at Aarhus University offer a new prospect on nucleic acids as a unique scaffold for macro-molecular prodrugs. With a natural mechanism for drug release they are foreseen to hold immense promise for targeted drug delivery.

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