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GlpG simulation paper published in PNAS

Posted on Jan. 6, 2016 | By Nicholas Schafer

A manuscript with the title “Topological constraints and modular structure in the folding and functional motions of GlpG, an intramembrane protease” has been published in PNAS. This paper uses simulations to investigate the effects of constraining the unfolded ensemble of GlpG in a bilayer on its folding mechanism. Using the detailed folding mechanisms found in this paper, we propose a possible source of the large number of negative phi-values found in our previous experimental work. Otzen lab co-authors include Nicholas P Schafer and Daniel E Otzen. This work is a collaboration with Kresten Lindorff-Larsen at Copenhagen University as well as Ha H Truong and Peter G Wolynes at Rice University.  


GlpG phi-value analysis published in PNAS

Posted on May 6, 2015 | By Nicholas Schafer

A manuscript with the title “Cooperative folding of a polytopic α-helical membrane protein involves a compact N-terminal nucleus and nonnative loops” has been published in PNAS. This manuscript describes the most comprehensive phi-value analysis of a membrane protein to-date. Co-authors in the Otzen group include Wojciech Paslawski, Ove K Lillelund, Julie Veje Kristensen, Nicholas P Schafer, and Daniel E Otzen. This work was a collaboration with Rosanna P Baker and Sinisa Urban at Johns Hopkins University.  


Funding awarded for membrane protein folding project

Posted on Dec. 15, 2014 | By Nicholas Schafer

Nick Schafer will be supported by the Carlsberg Foundation and DFF-FNU for a total of two years to work on a project entitled “Combining experiment and simulation to elucidate folding and stability of the alpha-helical TMP GlpG”.  


Cagla, Henriette and Camilla have successfully defended their master thesis

Posted on Sep. 30, 2014 | By Camillabertel

Marcel Stenvang goes to the Nanoscience Center at Beijing

Posted on Mar. 4, 2013 | By dao

Civilingeniør Frode V. Nyegaard og hustrus Fond

Posted on Feb. 4, 2013 | By dao

Daniel is awarded 250.000 kr from “Civilingeniør Frode V. Nyegaard og hustrus Fond” to buy apparatus
for protein purification.


Carlsberg Foundation award

Posted on Decæ 4, 2012 | By dao

Daniel is awarded 500.000 kr from the Carlsberg Foundation to buy apparatus for
biophysical characterization of proteins. See
www.carlsbergfondet.dk/en/Forskningsomraader/Artikler%20fra%20bevillingshavere/
Proteinernes%20kaededans.aspx for more information.  


Amyloid in plants

Posted on Jun. 4, 2012 | By dao

Daniel and Lars Kjær are awarded 2.151.608 kr from The Danish Council for Independent Research
| Natural Sciences for the project “Amyloid in plants”. Lars starts work in February 2013 as post-doc
in Daniel’s group from February 2013 for a 2-year period.  


Biosurfactants – Environmentally friendly Protein Partners (BEPP)

Posted on Jun. 4, 2012 | By dao

Dr. Kell K. Andersen is awarded 3.178.590 DKK from The Danish Council for Independent Research |
Technology and Production Sciences for the project
“Biosurfactants – Environmentally friendly Protein Partners (BEPP)”
which he will carry out together with Daniel Otzen.


Jon Gade successfully defends his PhD thesis

Posted on May 11, 2012 | By dao

  Jon Gade successfully defends his PhD thesis
“Aggregation of whey proteins – and their interactions with amphiphiles”.