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						<h1 itemprop="headline">Distinguished iNANO Lecture by Professor Dr. Camilla Foged, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen</h1>
						

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							<p class="text--intro" itemprop="description"><p>Next-generation mRNA vaccines: New RNA modalities and delivery systems</p></p>
						
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														Friday 21  November 2025,
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														&nbsp;at 10:15 -  11:00
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														<p>iNANO AUD (1593-012)</p>
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														Associate Professor Ken Howard (kenh@inano.au.dk)
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                Next-generation mRNA vaccines: New RNA modalities and delivery systems
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                    <p>RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of global significance, <em>e.g.</em>, infectious diseases. The highly successful messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were developed at record speed during the coronavirus disease 2019 pandemic. A consequence of this is exceptionally shortened vaccine development times, which in combination with adaptability makes the RNA vaccine technology highly attractive against infectious diseases and for pandemic preparedness. This presentation will cover state of the art in the design and delivery of RNA vaccines for infectious diseases based on different RNA modalities and discusses future perspectives for using next-generation RNA vaccines to combat pathogens beyond SARS-CoV-2.</p>
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    <p><strong>References</strong><br> Lokras, A.G. Bobak, T.R., Baghel, S.S., Sebastiani, F.<strong> </strong>and <strong>Foged, C.</strong> (2024): Advances in the design and delivery of RNA vaccines for infectious Diseases,&nbsp;<em>Adv. Drug. Deliv. Rev</em>. <a href="https://doi.org/10.1016/j.addr.2024.115419" target="_self">https://doi.org/10.1016/j.addr.2024.115419</a>.</p>
<p>Fougeroux, C., Hagen, S.H., Goksøyr, L., Aves, K.L., Okholm, A.K., Morin, C., Lokras, A.G., Baghel, S.S., <strong>Foged, C.</strong>, van de Vegte-Bolmer, M., van Gemert, G.-., Jore, M.M., Vidal-Calvo, E.E., Gustavsson, T., Salanti, A., Theander, T.G., Nielsen, M.A., de Jongh, W.A., Bertelsen, A.F.S.<sup> </sup>(2025)<sup>: </sup>A modular mRNA vaccine platform encoding antigen-presenting capsid virus-like particles enhances the immunogenicity of the malaria antigen Pfs25. <em>Nat. Nanotechnol.</em> <a href="https://doi.org/10.1038/s41565-025-01889-1" target="_self">https://doi.org/10.1038/s41565-025-01889-1</a>.</p>
<p><strong>Lokras, A., </strong>Baghel, S.S.,<strong> </strong>Jensen, R.F., <strong>Thakur, A., Franzyk, H., </strong>Thofte, O., Herrera-Barrera, M., Landry, M., <strong>Thanthrige, M.P., </strong>Beinat, C., <strong>Rades, T., </strong>Paludan, S.R., Riesbeck, K., Rosenkrands, I., <strong>Christensen, D., </strong>Pedersen, G.K., and <strong>Foged, C. </strong><strong>(2025):</strong> Cholesterol in mRNA-Lipid Nanoparticles Can Be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG-1<em>, Adv. Funct. Mat.</em> <a href="https://doi.org/10.1002/adfm.202505627" target="_self">https://doi.org/10.1002/adfm.202505627</a>.</p>
<p>Baghel, S., Lokras, A., Alves Dias, B., Landry, M., Cerdá, S.L., Wadhwa, A., Herrera-Barrera, M., <strong>Thakur, A., Rades, T., Franzyk, H., Hopkins, C., Sun, C., Christensen, D., Pedersen, G.K., </strong>Sahay, G. <strong>and Foged, C. </strong><strong>(2025):</strong><strong> </strong>Design of messenger RNA vaccines based on lipid-polymer hybrid nanoparticles, <em>J. Control. Release, </em><a href="https://doi.org/10.1016/j.jconrel.2025.114385" target="_blank" title="Persistent link using digital object identifier" rel="noreferrer">https://doi.org/10.1016/j.jconrel.2025.1143</a></p>


            
                



            
            
                



            
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