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						<h1 itemprop="headline">Specialized iNANO lecture</h1>
						
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														Wednesday 22  June 2022,
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														&nbsp;at 10:15 -  11:00
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														<p>1510-213 (AUD VI)</p>
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														Prof. Troels Skrydstrup (ts@chem.au.dk)
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									<h2><strong><a href="https://joliot.cea.fr/drf/joliot/Pages/Entites_de_recherche/medicaments_technologies_sante/SCBM/lmc.aspx" target="_self">Davide Audisio, CEA, Université Paris Saclay, Département Médicaments et Technologies pour la Santé, SCBM, 91191 Gif-sur-Yvette, France</a></strong></h2>
<h3><strong>Late state carbon-14 labeling and isotope exchange</strong></h3>
<p>Carbon-14 radiolabeling is a unique tool that, in association with -counting and -imaging technologies, provides vital knowledge on the fate of synthetic organic molecules such as pharmaceuticals and agrochemicals.1 Traditional multistep synthesis and the associated costs have limited its utilization.2<br> Recently, we have explored late-stage carbon isotope labeling technologies starting from readily available 14C sources, such as [14C]CO2, [14C]CO and [14C]CN-.3 In this context, we have developed transitions metal catalyzed and photocatalyzed methodologies, to enable effective carbon-isotope exchange on carboxylic acids and nitrile containing molecules.4 These reactions expand the concept of late-stage carbon radiolabeling and provide a direct access to end-use labeled pharmaceuticals.</p>
<p><strong>References</strong></p><ol> 	<li>&nbsp;E. M. Isin, C. S. Elmore, G. N. Nilsson, R. A. Thompson, L. Weidolf, Chem. Res. Toxicol. 2012, 25, 532.</li> 	<li>R. Voges, J. R. Heys, T. Moenius, in “Preparation of Compounds Labeled with Tritium and Carbon-14”, John Wiley &amp; Sons, Ltd, 2009, 393.</li> 	<li>a) G. Destro, O. Loreau, E. Marcon, F. Taran, T. Cantat, D. Audisio J. Am. Chem. Soc. 2019, 141, 780.<br> 	b) C. Kingston, M. A. Wallace, A. J. Allentoff, J. N. de Gruyter, J. S. Chen, S. X. Gong, S. Bonacorsi, Jr., P. S. Baran J. Am. Chem. Soc. 2019, 141, 774.<br> 	c) G. Destro, K. Horkka, O. Loreau, D.-A. Buisson, L. Kingston, A. Del Vecchio, M. Schou, C. S. Elmore, F. Taran, T. Cantat, D. Audisio Angew. Chem. Int. Ed. 2020, 59, 13490.</li> 	<li>M. Feng, J. De Oliveira, A. Sallustrau, G. Destro, P. Thuéry, S. Roy, T. Cantat, C. S. Elmore, J. Blankenstein, F. Taran, D. Audisio J. Am. Chem. Soc. 2021, 143, 5659.</li> </ol>
								
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