JØRGEN KJEMS: Nanomedicine

There are three main focus areas in the Kjems lab:

a) The understanding of how small non-coding RNA and circular RNA contribute to cell maintenance and disease development with a primary aim of defining new targets for disease intervention.

b) The creation of novel bioimaging and delivery systems for gene medicine including siRNA, miRNA mimics, antimiRs (antisense targeting microRNA) with a specific focus on inflammation, cancer, influenza, and regeneration of damaged tissue (tissue engineering).

c) Design and construction of functionalized self assembled DNA and RNA nanostructures capable of complex biosensing, coupled with controlled action e.g. drug release, enzyme activation, and receptor signaling.

In CellPAT, Jørgen Kjems contributes with key expertises in applied nanotechnology including biomolecular design, bioconjugation, cell delivery and tissue engineering as well as the more basic molecular biology fields of gene expression and cellular growth and development.

Recent publications

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Vieira de Sá, R., Sudria-Lopez, E., Cañizares Luna, M., Harschnitz, O., van den Heuvel, D. M. A., Kling, S., Vonk, D., Westeneng, H. J., Karst, H., Bloemenkamp, L., Varderidou-Minasian, S., Schlegel, D. K., Mars, M., Broekhoven, M. H., van Kronenburg, N. C. H., Adolfs, Y., Vangoor, V. R., de Jongh, R., Ljubikj, T. ... Pasterkamp, R. J. (2024). ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes. Nature Communications, 15(1), Article 7484. https://doi.org/10.1038/s41467-024-51676-0

Okholm, T. L. H., Kamstrup, A. B., Nielsen, M. M., Hollensen, A. K., Graversgaard, M. L., Sørensen, M. H., Kristensen, L. S., Vang, S., Park, S. S., Yeo, E., Dyrskjøt, L., Kjems, J., Pedersen, J. S. & Damgaard, C. K. (2024). circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA. eLife, 13, Article RP91783. https://doi.org/10.7554/eLife.91783

Rybiczka-Tešulov, M., Garritsen, O., Venø, M. T., Wieg, L., Dijk, R. V., Rahimi, K., Gomes-Duarte, A., Wit, M. D., van de Haar, L. L., Michels, L., van Kronenburg, N. C. H., van der Meer, C., Kjems, J., Vangoor, V. R. & Pasterkamp, R. J. (2024). Circular RNAs regulate neuron size and migration of midbrain dopamine neurons during development. Nature Communications, 15(1), Article 6773. https://doi.org/10.1038/s41467-024-51041-1

Scoyni, F., Sitnikova, V., Giudice, L., Korhonen, P., Trevisan, D. M., Hernandez de Sande, A., Gomez-Budia, M., Giniatullina, R., Ugidos, I. F., Dhungana, H., Pistono, C., Korvenlaita, N., Välimäki, N. N., Kangas, S. M., Hiltunen, A. E., Gribchenko, E., Kaikkonen-Määttä, M. U., Koistinaho, J., Ylä-Herttuala, S. ... Malm, T. (2024). ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling. Cell Reports, 43(3), Article 113862. https://doi.org/10.1016/j.celrep.2024.113862

Vangoor, V. R., Giuliani, G., de Wit, M., Rangel, C. K., Venø, M. T., Schulte, J. T., Gomes-Duarte, A., Senthilkumar, K., Puhakka, N., Kjems, J., de Graan, P. N. E. & Pasterkamp, R. J. (2024). Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy. Acta Neuropathologica, 148(1), Article 61. https://doi.org/10.1007/s00401-024-02817-8

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Revised 08.12.2025

Rikke Ploug Frydenberg