JØRGEN KJEMS: Nanomedicine

There are three main focus areas in the Kjems lab:

a) The understanding of how small non-coding RNA and circular RNA contribute to cell maintenance and disease development with a primary aim of defining new targets for disease intervention.

b) The creation of novel bioimaging and delivery systems for gene medicine including siRNA, miRNA mimics, antimiRs (antisense targeting microRNA) with a specific focus on inflammation, cancer, influenza, and regeneration of damaged tissue (tissue engineering).

c) Design and construction of functionalized self assembled DNA and RNA nanostructures capable of complex biosensing, coupled with controlled action e.g. drug release, enzyme activation, and receptor signaling.

In CellPAT, Jørgen Kjems contributes with key expertises in applied nanotechnology including biomolecular design, bioconjugation, cell delivery and tissue engineering as well as the more basic molecular biology fields of gene expression and cellular growth and development.

Recent publications

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Sükösd, Z., Swenson, M. S., Kjems, J. & Heitsch, C. E. (2013). Evaluating the accuracy of SHAPE-directed RNA secondary structure predictions. Nucleic Acids Research, 41(5), 2807-2816. https://doi.org/10.1093/nar/gks1283

Chen, M., Hein, S., Le, D. Q. S., Feng, W., Foss, M., Kjems, J., Besenbacher, F., Zou, X. & Bünger, C. (2013). Free radicals generated by tantalum implants antagonize the cytotoxic effect of doxorubicin. International Journal of Pharmaceutics, 448(1), 214-20. https://doi.org/10.1016/j.ijpharm.2013.03.041

Tan, C. L., Plotkin, J. L., Venø, M. T., von Schimmelmann, M., Feinberg, P., Mann, S., Handler, A., Kjems, J., Surmeier, D. J., O’Carroll, D., Greengard, P. & Schaefer, A. (2013). MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science, 342(6163), 1254-1258. https://doi.org/10.1126/science.1244193

Dang, J., Bian, Y., Sun, J., Chen, F., Dong, G.-Y., Liu, Q., Wang, X.-W., Kjems, J., Gao, S. & Wang, Q.-T. (2013). MicroRNA-137 promoter methylation in oral lichen planus and oral squamous cell carcinoma. Journal of Oral Pathology & Medicine, 42(4), 315-321. https://doi.org/10.1111/jop.12012

Wu, K., Song, W., Zhao, L., Liu, M., Yan, J., Andersen, M. Ø., Kjems, J., Gao, S. & Zhang, Y. (2013). MicroRNA functionalized microporous titanium oxide surface by lyophilization with enhanced osteogenic activity. A C S Applied Materials and Interfaces, 5(7), 2733-44. https://doi.org/10.1021/am400374c

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Full list of publications

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Lab website

Revised 08.12.2025

Rikke Ploug Frydenberg