JØRGEN KJEMS: Nanomedicine

There are three main focus areas in the Kjems lab:

a) The understanding of how small non-coding RNA and circular RNA contribute to cell maintenance and disease development with a primary aim of defining new targets for disease intervention.

b) The creation of novel bioimaging and delivery systems for gene medicine including siRNA, miRNA mimics, antimiRs (antisense targeting microRNA) with a specific focus on inflammation, cancer, influenza, and regeneration of damaged tissue (tissue engineering).

c) Design and construction of functionalized self assembled DNA and RNA nanostructures capable of complex biosensing, coupled with controlled action e.g. drug release, enzyme activation, and receptor signaling.

In CellPAT, Jørgen Kjems contributes with key expertises in applied nanotechnology including biomolecular design, bioconjugation, cell delivery and tissue engineering as well as the more basic molecular biology fields of gene expression and cellular growth and development.

Recent publications

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Zou, L., Luo, Y., Chen, M., Wang, G., Ding, M., Petersen, C. C., Kang, R., Dagnaes-Hansen, F., Zeng, Y., Lv, N., Ma, Q., Le, D. Q. S., Besenbacher, F., Bolund, L., Jensen, T. G., Kjems, J., Pu, W. T. & Bünger, C. (2013). A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds. Scientific Reports, 3, Article 2243. https://doi.org/10.1038/srep02243

Xu, W., Tan, Q., Yu, M., Sun, Q., Kong, H., Lægsgaard, E., Stensgaard, I., Kjems, J., Wang, J., Wang, C. & Besenbacher, F. (2013). Atomic-scale structures and interactions between the guanine quartet and potassium. Chemical Communications, 49(65), 7210-7212. https://doi.org/10.1039/c3cc43302a

Hossfeld, S., Nolte, A., Hartmann, H., Recke, M., Schaller, M., Walker, T., Kjems, J., Schlosshauer, B., Stoll, D., Wendel, H.-P. & Krastev, R. (2013). Bioactive coronary stent coating based on layer-by-layer technology for siRNA release. Acta Biomaterialia, 9(5), 6741-6752. https://doi.org/10.1016/j.actbio.2013.01.013

Lundin, K. E., Højland, T., Hansen, B., Persson, R., Bramsen, J. B., Kjems, J., Koch, T., Wengel, J. & Smith, C. I. E. (2013). Biological activity and biotechnological aspects of locked nucleic acids. Advances in Genetics, 82, 47-107. https://doi.org/10.1016/B978-0-12-407676-1.00002-0

Sükösd, Z., Knudsen, B., Anderson, J. WJ., Novák, A., Kjems, J. & Pedersen, C. N. S. (2013). Characterising RNA secondary structure space using information entropy. BMC Bioinformatics, 14 (Suppl 2), 1-9. Article S22. https://doi.org/10.1186/1471-2105-14-S2-S22

Displaying results 221 to 225 out of 434

Full list of publications

Group leader

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Lab website

Revised 08.12.2025

Rikke Ploug Frydenberg