Interdisciplinary Nanoscience Center

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 CellPAT STEFFEN THIEL: Innate Immune system

STEFFEN THIEL: Innate Immune system

Steffen Thiel’s research focus is the processes that create inflammation in the body and his group is among the leaders in the field of immune recognition.

Steffen Thiel has been deeply involved in the description of the proteins and processes in the part of the immune system referred to as the complement system.

Recent publications

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Bernth Jensen, J. M., Søgaard, O. S., Petersen, M. S., Hoffmann, S., Møller, B. K., Hansen, A. G., Sørensen, U. B. S. & Thiel, S. (2026). Isohemagglutinins exhibit synergistic polyreactivity toward Streptococcus pneumoniae surface antigens: implications for broad-spectrum reactivity of human antibodies. Medical Microbiology and Immunology, 215(1), Article 5. https://doi.org/10.1007/s00430-025-00862-y
Jensen, M., Thiel, S., Hansen, S. W. K., Palarasah, Y., Svenningsen, P. & Jensen, B. L. (2026). SGLT-2 inhibitors attenuate pattern recognition molecules collectin kidney 1 and mannose-binding lectin in kidney and liver in mice with diabetes. American journal of physiology. Renal physiology, 330(1), F17-F31. https://doi.org/10.1152/ajprenal.00184.2025
Mistegaard, C., Troldborg, A., Torgutalp, M., Loft, A. G., Thiel, S., Muche, B., Rios Rodriguez, V., Protopopov, M., Listing, J., Sieper, J., Poddubnyy, D. & Proft, F. (2025). Complement proteins in axial spondyloarthritis: associations with disease activity and TNFi treatment response in a multicentre RCT. Rheumatology Advances in Practice, 9(1), Article rkaf007. https://doi.org/10.1093/rap/rkaf007
Mistegaard, C., Troldborg, A., Torgutalp, M., Loft, A. G., Thiel, S., Muche, B., Rios Rodriguez, V., Protopopov, M., Listing, J., Sieper, J., Poddubnyy, D. & Proft, F. (2025). Complement system activation is associated with spinal radiographic progression in axial spondyloarthritis after 2 years of follow-up: findings from the CONSUL RCT. RMD Open, 11(4), Article e006087. https://doi.org/10.1136/rmdopen-2025-006087
Hymøller, K. M., Crone, L., Thiel, S. & Hennet, T. (2025). Differential Recognition of Lipopolysaccharide O-Antigens by the Pattern Recognition Molecules Mannan-Binding Lectin and Ficolins of the Complement System. Journal of Innate Immunity, 17(1), 397–413. https://doi.org/10.1159/000547441

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Group leader

Postal Address

Interdisciplinary Nanoscience Center (iNANO)

Gustav Wieds Vej 14

8000 Aarhus C

Denmark
Revised 08.12.2025
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Rikke Ploug Frydenberg