Steffen Thiel

Świerzko, A. S., Michalski, M., Sokołowska, A., Nowicki, M., Eppa, Ł., Szala-Poździej, A., Mitrus, I., Szmigielska-Kapłon, A., Sobczyk-Kruszelnicka, M., Michalak, K., Gołos, A., Wierzbowska, A., Giebel, S., Jamroziak, K., Kowalski, M. L., Brzezińska, O., Thiel, S., Jensenius, J. C., Kasperkiewicz, K. & Cedzyński, M. (2018). The Role of Complement Activating Collectins and Associated Serine Proteases in Patients With Hematological Malignancies, Receiving High-Dose Chemotherapy, and Autologous Hematopoietic Stem Cell Transplantations (Auto-HSCT). Frontiers in Immunology, 9, 2153. https://doi.org/10.3389/fimmu.2018.02153

Świerzko, A. S., Michalski, M., Sokołowska, A., Nowicki, M., Szala-Poździej, A., Eppa, Ł., Mitrus, I., Szmigielska-Kapłon, A., Sobczyk-Kruszelnicka, M., Michalak, K., Gołos, A., Wierzbowska, A., Giebel, S., Jamroziak, K., Kowalski, M. L., Brzezińska, O., Thiel, S., Matsushita, M., Jensenius, J. C. ... Cedzyński, M. (2020). Associations of Ficolins With Hematological Malignancies in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantations. Frontiers in Immunology, 10, [3097]. https://doi.org/10.3389/fimmu.2019.03097

Østergaard, J., Hansen, T. K., Thiel, S. & Flyvbjerg, A. (2005). Complement activation and diabetic vascular complications. Clin. Chim. Acta., 361, 10-19.

Østergaard, J., Thiel, S., Gadjeva, M., Hansen, T. K., Rasch, R. & Flyvbjerg, A. (2007). Mannose-binding lectin deficiency attenuates renal changes in a streptozotocin-induced model of type 1 diabetes in mice. Diabetologia, 50(7), 1541-1549.

Østergaard, J., Thiel, S., Hansen, T. K., Rasch, R. & Flyvbjerg, A. (2011). Comment on: Lin et al. (2010) Immune Cell-Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin. Diabetes;59: 2247-2252. Diabetes, 60(1), e7-8. https://doi.org/10.2337/db10-1298

Østergaard, J., Thiel, S., Hansen, T. K., Rasch, R. & Flyvbjerg, A. (2011). The role of complement C3 in the pathogenesis of diabetic kidney disease in a murine model of type 1 diabetes. Diabetes, e7.

Østergaard, J. A., Bjerre, M., RamachandraRao, S. P., Sharma, A. K., Nyengaard, J. R., Hansen, T. K., Thiel, S. & Flyvbjerg, A. (2012). Mannan-binding lectin in diabetic kidney disease: the impact of mouse genetics in a type 1 diabetes model. Experimental Diabetes Research, 2012, 678381. https://doi.org/10.1155/2012/678381

Østergaard, J., Bjerre, M., Dagnaes-Hansen, F., Hansen, T. K., Thiel, S. & Flyvbjerg, A. (2013). Diabetes-induced changes in mannan-binding lectin levels and complement activation in a mouse model of type 1 diabetes. Scandinavian Journal of Immunology, 77(3), 187-94. https://doi.org/10.1111/sji.12027

Østergaard, J., Thiel, S., Gadjeva, M., Hansen, T. K., Rasch, R. & Flyvbjerg, A. (2007). Mannose-binding lectin deficiency attenuates renal changes in a streptozotocin-induced model of type 1 diabetes in mice. Diabetologia, 50(7), 1541-9. https://doi.org/10.1007/s00125-007-0686-0

Østergaard, J., Hansen, T. K., Thiel, S. & Flyvbjerg, A. (2005). Complement activation and diabetic vascular complications. Clinica Chimica Acta, 361(1-2), 10-9. https://doi.org/10.1016/j.cccn.2005.04.028

Østergaard, J. A., Thiel, S., Hovind, P., Holt, C. B., Parving, H-H., Flyvbjerg, A., Rossing, P. & Hansen, T. K. (2014). Association of the pattern recognition molecule H-ficolin with incident microalbuminuria in an inception cohort of newly diagnosed type 1 diabetic patients: an 18 year follow-up study. Diabetologia, 57(10), 2201-7. https://doi.org/10.1007/s00125-014-3332-7

Østergaard, J. A., Thiel, S., Lajer, M., Steffensen, R., Parving, H-H., Flyvbjerg, A., Rossing, P., Tarnow, L. & Hansen, T. K. (2015). Increased All-Cause Mortality in Patients With Type 1 Diabetes and High-Expression Mannan-Binding Lectin Genotypes: A 12-Year Follow-up Study. Diabetes Care, 38(10), 1898-1903. https://doi.org/10.2337/dc15-0851

Østergaard, J. A., Ruseva, M. M., Malik, T. H., Hoffmann-Petersen, I. T., Pickering, M. C., Thiel, S. & Hansen, T. K. (2016). Increased Autoreactivity of the Complement-Activating Molecule Mannan-Binding Lectin in a Type 1 Diabetes Model. Journal of Diabetes Research, 2016, 1825738. https://doi.org/10.1155/2016/1825738

van Emmerik, L. C., Kuijper, E. J., Fijen, C. A., Dankert, J. & Thiel, S. (1994). Binding of mannan-binding protein to various bacterial pathogens of meningitis. Clinical and Experimental Immunology, 97(3), 411-6.

Zhang, M., Takahashi, K., Alicot, E. M., Vorup-Jensen, T., Kessler, B., Thiel, S., Jensenius, J. C., Ezekowitz, R. A., Moore, F. D. & Carroll, M. C. (2006). Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. J. Immunol., 177, 4727-34.

Zhang, J., Koh, J., Lu, J., Thiel, S., Leong, B. S. H., Sethi, S., He, C. Y. X., Ho, B. & Ding, J. L. (2009). Local inflammation induces complement crosstalk which amplifies the antimicrobial response. P L o S Pathogens, 5(1), e1000282. https://doi.org/10.1371/journal.ppat.1000282

Zhang, M., Takahashi, K., Alicot, E. M., Vorup-Jensen, T., Kessler, B., Thiel, S., Jensenius, J. C., Ezekowitz, R. A. B., Moore, F. D. & Carroll, M. C. (2006). Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. Journal of Immunology, 177(7), 4727-34.

Zarantonello, A., Presumey, J., Simoni, L., Yalcin, E., Fox, R., Hansen, A., Olesen, H. G., Thiel, S., Johnson, M. B., Stevens, B., Laursen, N. S., Carroll, M. C. & Andersen, G. R. (2020). An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase. Journal of Immunology, 205(6), 1678-1694. https://doi.org/10.4049/jimmunol.2000528

Zacho, R. M., Jensen, L., Terp, R., Jensenius, J. C. & Thiel, S. (2012). Studies of the pattern recognition molecule H-ficolin: specificity and purification. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M111.301044

Ytting, H., Christensen, I. J., Jensenius, J. C., Thiel, S. & Nielsen, H. J. (2005). Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer. Cancer Immunology, Immunotherapy, 54, 265-272.

Ytting, H., Christensen, I. J., Thiel, S., Jensenius, J. C. & Nielsen, H. J. (2005). Serum mannan-binding lectin-associated serine protease 2 levels in colorectal cancer: relation to recurrence and mortality. Clinical Cancer Research, 11, 1441-1446.

Ytting, H., Jensenius, J. C., Christensen, I. J., Thiel, S. & Nielsen, H. J. (2004). Increased activity of the mannan-binding lectin complement activation pathway in patients with colorectal cancer. Scandinavian Journal of Gastroenterology, 39, 674-679.

Ytting, H., Christensen, I. J., Basse, L., Lykke, J., Thiel, S., Jensenius, J. C. & Nielsen, H. J. (2006). Influence of major surgery on the mannan-binding lectin pathway of innate immunity. Clin. Exp. Immunol., 144, 239-46.

Ytting, H., Christensen, IJ., Thiel, S., Jensenius, J. C., Svendsen, MN., Nielsen, L., Lottenburger, T. & Nielsen, HJ. (2007). Biological variation in circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease-2 and the influence of age, gender and physical exercise. Scand. J. Immunol., 66, 458-64.

Ytting, H., Christensen, IJ., Thiel, S., Jensenius, J. C. & Nielsen, HJ. (2008). Pre- and postoperative levels in serum of mannan-binding lectin associated serine protease-2 -a prognostic marker in colorectal cancer. Human Immunology, 69, 414-20.

Ytting, H., Christensen, I. J., Steffensen, R. N., Alsner, J., Thiel, S., Jensenius, J. C., Hansen, U. & Nielsen, H. J. (2011). Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer. Scandinavian Journal of Immunology, 73(2), 122-7. https://doi.org/10.1111/j.1365-3083.2010.02480.x

Ytting, H., Christensen, I. J., Thiel, S., Jensenius, J. C. & Nielsen, H. J. (2008). Pre- and postoperative levels in serum of mannan-binding lectin associated serine protease-2 -a prognostic marker in colorectal cancer. Human Immunology, 69(7), 414-20. https://doi.org/10.1016/j.humimm.2008.05.005

Ytting, H., Christensen, I. J., Thiel, S., Jensenius, J. C., Svendsen, M., Nielsen, L., Lottenburger, T. & Nielsen, H. J. (2007). Biological variation in circulating levels of mannan-binding lectin (MBL) and MBL-associated serine protease-2 and the influence of age, gender and physical exercise. Scandinavian Journal of Immunology, 66(4), 458-64. https://doi.org/10.1111/j.1365-3083.2007.01991.x

Ytting, H., Christensen, I. J., Basse, L., Lykke, J., Thiel, S., Jensenius, J. C. & Nielsen, H. J. (2006). Influence of major surgery on the mannan-binding lectin pathway of innate immunity. Clinical and Experimental Immunology, 144(2), 239-46. https://doi.org/10.1111/j.1365-2249.2006.03068.x

Ytting, H., Christensen, I. J., Thiel, S., Jensenius, J. C. & Nielsen, H. J. (2005). Serum mannan-binding lectin-associated serine protease 2 levels in colorectal cancer: relation to recurrence and mortality. Clinical Cancer Research, 11(4), 1441-6. https://doi.org/10.1158/1078-0432.CCR-04-1272

Ytting, H., Christensen, I. J., Jensenius, J. C., Thiel, S. & Nielsen, H. J. (2005). Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer. Cancer Immunology, Immunotherapy, 54(3), 265-72. https://doi.org/10.1007/s00262-004-0594-9

Ytting, H., Jensenius, J. C., Christensen, I. J., Thiel, S. & Nielsen, H. J. (2004). Increased activity of the mannan-binding lectin complement activation pathway in patients with colorectal cancer. Scandinavian Journal of Gastroenterology, 39(7), 674-9. https://doi.org/10.1080/00365520410005603

Yatime, L., Merle, N. S., Hansen, A. G., Friis, N. A., Østergaard, J. A., Bjerre, M., Roumenina, L. T., Thiel, S., Kristensen, P. & Andersen, G. R. (2018). A single-domain antibody targeting complement component c5 acts as a selective inhibitor of the terminal pathway of the complement system and thus functionally mimicks the c-terminal domain of the staphylococcus aureusSSL7 protein. Frontiers in Immunology, 9, [2822]. https://doi.org/10.3389/fimmu.2018.02822

Wittenborn, T., Thiel, S., Jensen, L., Nielsen, HJ. & Jensenius, J. C. (2009). Characteristics and biological variations of M-ficolin, a pattern recognition molecule. Journal of Innate Immunity.

Wittenborn, T., Thiel, S., Jensen, L., Nielsen, H. J. & Jensenius, J. C. (2010). Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma. Journal of Innate Immunity, 2(2), 167-80. https://doi.org/10.1159/000218324

White, M. R., Tripathi, S., Verma, A., Kingma, P., Takahashi, K., Jensenius, J., Thiel, S., Wang, G., Crouch, E. C. & Hartshorn, K. L. (2017). Collectins, H-ficolin and LL-37 reduce influence viral replication in human monocytes and modulate virus-induced cytokine production. Innate Immunity, 23(1), 77-88. https://doi.org/10.1177/1753425916678470

Weinschutz Mendes, H., Boldt, A. W., Stahlke, E., Jensenius, J. C., Thiel, S. & Messias-Reason, I. J. T. (2020). Adding MASP1 to the lectin pathway-Leprosy association puzzle: Hints from gene polymorphisms and protein levels. PLOS Neglected Tropical Diseases , 14(4), [e0007534]. https://doi.org/10.1371/journal.pntd.0007534

Vorup-Jensen, T., Jensenius, J. C. & Thiel, S. (1998). MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway. Immunobiology, 199, 348-57.

Vorup-Jensen, T., Petersen, S. V., Hansen, A. G., Poulsen, K., Schwaeble, W., Sim, R. B., Reid, K. B., Davis, S. J., Thiel, S. & Jensenius, J. C. (2000). Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2. Journal of Immunology, 165(4), 2093-100.

Vorup-Jensen, T., Jensen, U. B., Liu, H., Kawasaki, T., Uemura, K., Thiel, S., Dagnaes-Hansen, F. & Jensen, T. G. (2001). Tail-vein injection of mannan-binding lectin DNA leads to high expression levels of multimeric protein in liver. Molecular Therapy, 3(6), 867-74. https://doi.org/10.1006/mthe.2001.0335

Vorup-Jensen, T., Sørensen, E. S., Jensen, U. B., Schwaeble, W., Kawasaki, T., Ma, Y., Uemura, K., Wakamiya, N., Suzuki, Y., Jensen, T. G., Takahashi, K., Ezekowitz, R. A., Thiel, S. & Jensenius, J. C. (2001). Recombinant expression of human mannan-binding lectin. International Immunopharmacology, 1(4), 677-87.

Vorup-Jensen, T., Jensenius, J. C. & Thiel, S. (1998). MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway. Immunobiology, 199(2), 348-57.

Verma, A., White, M., Vathipadiekal, V., Tripathi, S., Mbianda, J., Ieong, M., Qi, L., Taubenberger, J. K., Takahashi, K., Jensenius, J. C., Thiel, S. & Hartshorn, K. L. (2012). Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses. Journal of Immunology, 189(5), 2478-87. https://doi.org/10.4049/jimmunol.1103786

Varga, L., Szilagyi, K., Lorincz, Z., Berrens, L., Thiel, S., Zavodszky, P., Daha, M. R., Thielens, N. M., Arlaud, G. J., Nagy, K., Spath, P. & Fust, G. (2003). Studies on the mechanisms of allergen-induced activation of the classical and lectin pathways of complement. Molecular Immunology, 39, 839-846.

Varga, L., Szilágyi, K., Lõrincz, Z., Berrens, L., Thiel, S., Závodszky, P., Daha, M. R., Thielens, N. M., Arlaud, G. J., Nagy, K., Späth, P. & Füst, G. (2003). Studies on the mechanisms of allergen-induced activation of the classical and lectin pathways of complement. Molecular Immunology, 39(14), 839-46.

Valdimarsson, H., Stefansson, M., Vikingsdottir, T., Arason, G. J., Koch, C., Thiel, S. & Jensenius, J. C. (1998). Reconstitution of opsonizing activity by infusion of mannan-binding lectin (MBL) to MBL-deficient humans. Scandinavian Journal of Immunology, 48(2), 116-23.

Uemura, K., Saka, M., Nakagawa, T., Kawasaki, N., Thiel, S., Jensenius, J. C. & Kawasaki, T. (2002). L-MBP is expressed in epithelial cells of mouse small intestine. Mianyixue Zazhi, 15, 6945-6950.

Uemura, K., Saka, M., Nakagawa, T., Kawasaki, N., Thiel, S., Jensenius, J. C. & Kawasaki, T. (2002). L-MBP is expressed in epithelial cells of mouse small intestine. Journal of Immunology, 169(12), 6945-50.