Steffen Thiel

Andersen, V., Holmskov, U., Sørensen, S. B., Jawhara, M., Andersen, K. W., Bygum, A., Hvid, L., Grauslund, J., Wied, J., Glerup, H., Fredberg, U., Villadsen, J. A., Kjær, S. G., Fallingborg, J., Moghadd, S. A. G. R., Knudsen, T., Brodersen, J., Frøjk, J., Dahlerup, J. F. ... Ellingsen, T. (2017). A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine. Nutrients, 9(5), [499]. https://doi.org/10.3390/nu9050499

Jensen, R. K., Pihl, R., Laursen, N. S., Thiel, S. & Andersen, G. R. (2017). A novel nanobody inhibitor of the alternative pathway. Molecular Immunology, 89, 198. https://doi.org/10.1016/j.molimm.2017.06.207

Pihl, R., Jensen, L., Hansen, A. G., Thøgersen, I. B., Andres, S., Dagnæs-Hansen, F., Oexle, K., Enghild, J. J. & Thiel, S. (2017). Analysis of Factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement. Journal of Immunology, 199(6), 2158-2170. https://doi.org/10.4049/jimmunol.1700518

Smedbråten, J., Sagedal, S., Åsberg, A., Hartmann, A., Rollag, H., Mjøen, G., Fagerland, M. W., Hansen, S. W. K., Mollnes, T. E. & Thiel, S. (2017). Collectin Liver 1 and Collectin Kidney 1 of the Lectin Complement Pathway Are Associated With Mortality After Kidney Transplantation. American Journal of Transplantation (Online), 17(1), 265-271. https://doi.org/10.1111/ajt.13933

White, M. R., Tripathi, S., Verma, A., Kingma, P., Takahashi, K., Jensenius, J., Thiel, S., Wang, G., Crouch, E. C. & Hartshorn, K. L. (2017). Collectins, H-ficolin and LL-37 reduce influence viral replication in human monocytes and modulate virus-induced cytokine production. Innate Immunity, 23(1), 77-88. https://doi.org/10.1177/1753425916678470

Axelgaard, E., Østergaard, J. A., Thiel, S. & Hansen, T. K. (2017). Diabetes Is Associated with Increased Autoreactivity of Mannan-Binding Lectin. Journal of Diabetes Research, Volume 2017, [6368780]. https://www.hindawi.com/journals/jdr/2017/6368780/

Dørflinger, G. H., Holt, C. B., Thiel, S., Østergaard, J. A. & Hansen, T. K. (2017). Effect of Optimization of Glycaemic Control on Mannan-Binding Lectin in Type 1 Diabetes. Journal of Diabetes Research, 2017, [1249729]. https://doi.org/10.1155/2017/1249729

Mortensen, S. A., Skov, L. L., Kjaer-Sorensen, K., Hansen, A. G., Hansen, S., Dagnæs-Hansen, F., Jensenius, J. C., Oxvig, C., Thiel, S. & Degn, S. E. (2017). Endogenous Natural Complement Inhibitor Regulates Cardiac Development. Journal of Immunology, 198(8), 3118-3126. https://doi.org/10.4049/jimmunol.1601958

Oroszlán, G., Dani, R., Szilágyi, A., Závodszky, P., Thiel, S., Gál, P. & Dobó, J. (2017). Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism. Frontiers in Immunology, 8, 1821. https://doi.org/10.3389/fimmu.2017.01821

Llull, L., Thiel, S., Amaro, S., Cervera, Á., Planas, A. M. & Chamorro, Á. (2017). Ficolin-1 Levels in Patients Developing Vasospasm and Cerebral Ischemia After Spontaneous Subarachnoid Hemorrhage. Molecular Neurobiology, 54(8), 6572-6580. https://doi.org/10.1007/s12035-016-0180-0

Pedersen, D. V., Roumenina, L. T., Jensen, R. K., Gadeberg, T. A., Marinozzi, C., Picard, C., Rybkine, T., Thiel, S., Sørensen, U. B., Stover, C., Fremeaux-Bacchi, V. & Andersen, G. R. (2017). Functional and structural insight into properdin control of complement alternative pathway amplification. E M B O Journal, 36(8). https://doi.org/10.15252/embj.201696173

Axelgaard, E., Østergaard, J. A., Haxha, S., Thiel, S. & Hansen, T. K. (2017). Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes. Mediators of Inflammation, 2017, [9403754]. https://doi.org/10.1155/2017/9403754

Ostergaard, J. A., Thiel, S., Hoffmann-Petersen, I. T., Hovind, P., Parving, H-H., Tarnow, L., Rossing, P. & Hansen, T. K. (2017). Incident microalbuminuria and complement factor mannan-binding lectin-associated protein 19 in people with newly diagnosed type 1 diabetes. Diabetes/Metabolism Research and Reviews, 33(5), [e2895 ]. https://doi.org/10.1002/dmrr.2895

Troldborg, A., Hansen, A. G., Hansen, S. W. K., Jensenius, J. C., Stengaard-Pedersen, K. & Thiel, S. (2017). Lectin Complement Pathway Proteins in Healthy Individuals. Clinical and Experimental Immunology, 188(1), 138–147 . https://doi.org/10.1111/cei.12909

Jensen, K., Lund, K. P., Christensen, K. B., Holm, A. T., Dubey, L. K., Moeller, J. B., Jepsen, C. S., Schlosser, A., Galgóczy, L., Thiel, S., Holmskov, U. & Sorensen, G. L. (2017). M-ficolin is present in Aspergillus fumigatus infected lung and modulates epithelial cell immune responses elicited by fungal cell wall polysaccharides. Virulence, 8(8), 1870-1879. https://doi.org/10.1080/21505594.2016.1278337

Krogh, S. S., Holt, C. B., Steffensen, R., Funck, K. L., Høyem, P., Laugesen, E., Poulsen, P. L., Thiel, S. & Hansen, T. K. (2017). Plasma levels of MASP-1, MASP-3 and MAp44 in patients with type 2 diabetes - influence of glycaemic control, body composition and polymorphisms in the MASP1 gene. Clinical and Experimental Immunology, 189(1), 103-112. https://doi.org/10.1111/cei.12963

Mortensen, S. A., Sander, B., Jensen, R. K., Pedersen, J. S., Golas, M., Jensenius, J. C., Hansen, A. G., Thiel, S. & Andersen, G. R. (2017). Reply to Arlaud et al. Structure of the C1 complex and the unbound C1r2s2 tetramer. Proceedings of the National Academy of Sciences of the United States of America, 114(29), E5768-E5770. https://doi.org/10.1073/pnas.1704353114

Pedersen, D. V., Roumenina, L., Jensen, R. K., Gadeberg, T. A. F., Marinozzi, C., Picard, C., Rybkine, T., Thiele, S., Sorensen, U. B. S., Stover, C., Fremeaux-Bacchi, V. & Andersen, G. R. (2017). Structural and functional studies of human complement factor P. Molecular Immunology, 89(Special issue: EMCHD2017), 197-198. https://doi.org/10.1016/j.molimm.2017.06.206

Mortensen, S. A., Sander, B., Jensen, R. K., Pedersen, J. S., Golas, M. M., Jensenius, J. C., Hansen, A. G., Thiel, S. & Andersen, G. R. (2017). Structure and activation of C1, the complex initiating the classical pathway of the complement cascade. Proceedings of the National Academy of Sciences of the United States of America, 114(5), 986-991. https://doi.org/10.1073/pnas.1616998114

Osthoff, M., Wojtowicz, A., Tissot, F., Jørgensen, C., Thiel, S., Zimmerli, S., Marchetti, O., Khanna, N., Bochud, P-Y., Trendelenburg, M. & Fungal Infection Network of Switzerland (FUNGINOS) (2016). Association of lectin pathway proteins with intra-abdominal Candida infection in high-risk surgical intensive-care unit patients. A prospective cohort study within the fungal infection network of Switzerland. Journal of Infection, 72(3), 377-85. https://doi.org/10.1016/j.jinf.2015.12.011

Banda, N. K., Acharya, S., Scheinman, R. I., Mehta, G., Takahashi, M., Thiel, S., Sekine, H., Fujita, T. & Holers, V. M. (2016). Complement mannan-binding lectin associated serine proteases 1 and 3 generated by allo-liver transplantation cleave in vivo pro-Factor D generated by the adipose tissue into active Factor D. Journal of Immunology, 196(1 Supplement).

Hertle, E., Arts, I. C. W., van der Kallen, C. J. H., Feskens, E. J. M., Schalkwijk, C. G., Hoffmann-Petersen, I. T., Thiel, S., Stehouwer, C. D. A. & van Greevenbroek, M. M. J. (2016). Distinct Longitudinal Associations of MBL, MASP-1, MASP-2, MASP-3, and MAp44 With Endothelial Dysfunction and Intima-Media Thickness: The Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) Study. Arteriosclerosis, Thrombosis, and Vascular Biology, 36(6), 1278-85. https://doi.org/10.1161/ATVBAHA.115.306552

Østergaard, J. A., Ruseva, M. M., Malik, T. H., Hoffmann-Petersen, I. T., Pickering, M. C., Thiel, S. & Hansen, T. K. (2016). Increased Autoreactivity of the Complement-Activating Molecule Mannan-Binding Lectin in a Type 1 Diabetes Model. Journal of Diabetes Research, 2016, 1825738. https://doi.org/10.1155/2016/1825738

Bro-Jeppesen, J., Kjaergaard, J., Thiel, S., Jensenius, J. C., Bjerre, M., Wanscher, M., Christensen, J. V. & Hassager, C. (2016). Influence of mannan-binding lectin and MAp44 on outcome in comatose survivors of out-of-hospital cardiac arrest. Resuscitation, 101, 27-34. https://doi.org/10.1016/j.resuscitation.2016.01.007

Smedbråten, J., Mjøen, G., Hartmann, A., Åsberg, A., Rollag, H., Mollnes, T. E., Sandvik, L., Fagerland, M. W., Thiel, S. & Sagedal, S. (2016). Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients. BMC Nephrology, 17(1), 148. https://doi.org/10.1186/s12882-016-0373-9

Banda, N. K., Acharya, S., Scheinman, R. I., Mehta, G., Coulombe, M., Takahashi, M., Sekine, H., Thiel, S., Fujita, T. & Holers, V. M. (2016). Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing. Journal of Immunology, 197(9), 3680-3694. https://doi.org/10.4049/jimmunol.1600719

Kjaer, T. R., Jensen, L., Hansen, A., Dani, R., Jensenius, J. C., Dobó, J., Gál, P. & Thiel, S. (2016). Oligomerization of mannan-binding lectin dictates binding properties and complement activation. Scandinavian Journal of Immunology, 84(1). https://doi.org/10.1111/sji.12441

Ingels, C., Vanhorebeek, I., Derese, I., Jensen, L., Wouters, P. J., Thiel, S. & Van den Berghe, G. (2016). The pattern recognition molecule collectin-L1 in critically ill children. Pediatric Research, 80(2), 237-43. https://doi.org/10.1038/pr.2016.76

Troldborg, A., Thiel, S., Jensen, L., Hansen, S. W. K., Laska, M. J., Deleuran, B., Jensenius, J. C. & Stengaard-Pedersen, K. (2015). CL-L1 and CL-K1 and other complement associated pattern recognition molecules in systemic lupus erythematosus. Clinical and Experimental Immunology. https://doi.org/10.1111/cei.12678

Laursen, T. L., Sandahl, T. D., Støy, S., Schiødt, F. V., Lee, W. M., Vilstrup, H., Thiel, S. & Grønbaek, H. (2015). Circulating mannan-binding lectin, M-, L-, H-ficolin and collectin-liver-1 levels in patients with acute liver failure. Liver International, 35(3), 756-63. https://doi.org/10.1111/liv.12682

Bajic, G., Degn, S. E., Thiel, S. & Andersen, G. R. (2015). Complement activation, regulation, and molecular basis for complement-related diseases. E M B O Journal, 34(22), 2735-2757. https://doi.org/10.15252/embj.201591881

Storm, L., Christensen, I. J., Jensenius, J. C., Nielsen, H. J., Thiel, S. & Danish Study Group on Early Detection of Colorectal Cancer (2015). Evaluation of complement proteins as screening markers for colorectal cancer. Cancer Immunology, Immunotherapy, 64(1), 41-50. https://doi.org/10.1007/s00262-014-1615-y

Holt, C. B., Østergaard, J. A., Axelgaard, E., Nielsen, G. K., Endo, Y., Thiel, S. & Hansen, T. K. (2015). Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes. Mediators of Inflammation, 2015, 653260. https://doi.org/10.1155/2015/653260

Bayarri-Olmos, R., Hansen, S., Henriksen, M. L., Storm, L., Thiel, S., Garred, P. & Munthe-Fog, L. (2015). Genetic variation of COLEC10 and COLEC11 and association with serum levels of collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1). PLOS ONE, 10(2), e0114883. https://doi.org/10.1371/journal.pone.0114883

Smedbråten, Y. V., Sagedal, S., Mjøen, G., Hartmann, A., Fagerland, M. W., Rollag, H., Mollnes, T. E. & Thiel, S. (2015). High ficolin-3 level at the time of transplantation is an independent risk factor for graft loss in kidney transplant recipients. Transplantation, 99(4), 791-6. https://doi.org/10.1097/TP.0000000000000422

Østergaard, J. A., Thiel, S., Lajer, M., Steffensen, R., Parving, H-H., Flyvbjerg, A., Rossing, P., Tarnow, L. & Hansen, T. K. (2015). Increased All-Cause Mortality in Patients With Type 1 Diabetes and High-Expression Mannan-Binding Lectin Genotypes: A 12-Year Follow-up Study. Diabetes Care, 38(10), 1898-1903. https://doi.org/10.2337/dc15-0851

Petri, C., Thiel, S., Jensenius, J. C. & Herlin, T. (2015). Investigation of Complement-activating Pattern Recognition Molecules and Associated Enzymes as Possible Inflammatory Markers in Oligoarticular and Systemic Juvenile Idiopathic Arthritis. Journal of Rheumatology, 42(7), 1252-8. https://doi.org/10.3899/jrheum.141449

Troldborg, A., Thiel, S., Laska, M. J., Deleuran, B., Jensenius, J. C. & Stengaard-Pedersen, K. (2015). Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus. Journal of Rheumatology, 42(6), 948-51. https://doi.org/10.3899/jrheum.141163

Atik, T., Koparir, A., Bademci, G., Foster, J., Altunoglu, U., Mutlu, G. Y., Bowdin, S., Elcioglu, N., Tayfun, G. A., Atik, S. S., Ozen, M., Ozkinay, F., Alanay, Y., Kayserili, H., Thiel, S. & Tekin, M. (2015). Novel MASP1 mutations are associated with an expanded phenotype in 3MC1 syndrome. Orphanet Journal of Rare Diseases, 10, 128. https://doi.org/10.1186/s13023-015-0345-3

Jenny, L., Ajjan, R., King, R., Thiel, S. & Schroeder, V. (2015). Plasma levels of mannan-binding lectin-associated serine proteases MASP-1 and MASP-2 are elevated in type 1 diabetes and correlate with glycaemic control. Clinical and Experimental Immunology, 180(2), 227-32. https://doi.org/10.1111/cei.12574

Troldborg, A., Thiel, S., Laska, M. J., Deleuran, B. W., Jensenius, J. C. & Stengaard-Pedersen, K. (2015). Plasma levels of the serine proteases and associated proteins of the Lectin Pathway are altered in SLE patients. Molecular Immunology, 67(1).

Kjaer, T. R., Le, L. T. M., Pedersen, J. S., Sander, B., Golas, M. M., Jensenius, J. C., Andersen, G. R. & Thiel, S. (2015). Structural Insights into the Initiating Complex of the Lectin Pathway of Complement Activation. Structure, 23(2), 342-351. https://doi.org/10.1016/j.str.2014.10.024