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Publications 2019


A new class of recombinant human albumin with multiple surface thiols exhibits stable conjugation and enhanced FcRn binding and blood circulation Schelde, K. K.; Nicholls, K.; Dagnæs-Hansen, F.; Rawsthorne, H.; Andersen, B.; Finnis, C. J. A.; Williamson, M.; Cameron, J.; Howard, K. A. J Biol. Chem. 2019, 294, 3735-3743. https://doi.org/10.1074/jbc.RA118.005870


Optimised approach to albumin–drug conjugates using monobromomaleimide-C-2 linkers Wall, A.; Nicholls, K.; Caspersen, M. B.; Skrivergaard, S.; Howard, K. A.; Karu, K.; Chudasama, V.; Baker, J. R. Org. Biomol. Chem. 2019, 17, 7870-7873, https://doi.org/10.1039/C9OB00721K


Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis Garcia, J. P.;  Stein, J.; Cai, Y.; Riemers, F.; Wexselblatt, E.; Wengel, J. Tryfonidous, M.; Yayon, A.; Howard, K. A.; Creemers, L. B., J. Contol Release, 2019, 294, 247-258, https://doi.org/10.1016/j.jconrel.2018.12.030


Cellular uptake of covalent and non-covalent DNA nanostructures with different sizes and geometries Raniolo, S.; Croce, S.; Thomsen, R. P.; Okholm, A. H.; Unida, V.; Iacovelli, F.; Manetto, A.; Kjems, J.; Desideri, A.; Biocca, S., Nanoscale, 2019, 11, 10808-10818,  https://doi.org/10.1039/C9NR02006C


An RNA Origami Octahedron with Intrinsic siRNAs for Potent Gene Knockdown Høiberg, H.C.; Sparvath, S. M.; Andersen, V. L.; Kjems, J.; Andersen, E. S., Biotechnol J. 2019, 14, e1700634, https://doi.org/doi:10.1002/biot.201700634


Genetically-encoded, functional single-strand RNA origami Krissanaprasit, A.; Key, C.; Fergione, M..; Froehlich, K.; Pontula, S.; Hart, M.; Carriel, P.; Kjems, J.; Andersen, E. S.; LaBean, T. H. Anticoagulant Adv. Mat,. 2019, 31, e1808262, https://doi:10.1002/adma.201808262


Toehold-Mediated Strand Displacement in a Triplex Forming Nucleic Acid Clamp for Reversible Regulation of Polymerase Activity and Protein Expression Nguyen, T. J. D.; Manuguerra, I.; Kumar, V.; Gothelf, K. V. Chemistry 2019, 25, 12303-12307, https://doi.org/10.1002/chem.201903496


Aptamer-Directed Conjugation of DNA to Therapeutic Antibodies Skovsgaard, M. B.; Mortensen, M. R.; Palmfeldt, J.; Gothelf, K. V. Bioconjugate Chem 2019, 30, 2127-2135. https://doi.org/10.1021/acs.bioconjchem.9b00363


Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside    Analogues Krüger, F.; Kumar, V.; Monge, P.; Conzelmann, C.; Smith, N.; Gothelf, K. V.; Tolstrup, M.; Münch, J.; Zelikin, A. N. Adv. Sci. 2019, 6, 1802095. https://doi.org/10.1002/advs.201802095


Selective delivery of doxorubicin to EGFR+ cancer cells by Cetuximab‐DNA conjugates Liu, T.; Song, P.; Märcher, A.; Kjems, J.; Yang, C.; Gothelf, K. V. ChemBioChem, 2019, 20. 1014-1018. https://doi.org/10.1002/cbic.201800685


A Self-Assembled, Modular Nucleic Acid-Based Nanoscaffold for multivalent Theranostic Medicine Andersen, V. L.; Vinther, M.; Kumar, R.; Ries, A.; Wengel, J.; Nielsen, J. S.; Kjems, J. Theranostics 2019, 9, 2662-2677 https://doi.org/10.7150/thno.32060


Peptide-Directed DNA-Templated Protein Labelling for The Assembly of a Pseudo-IgM Nielsen, T. B.; Thomsen, R. P.; Mortensen, M. R.; Kjems, J.; Nielsen, P. F.; Nielsen, T. E.; Kodal, A. L. B.; Clo, E.; Gothelf, K. V. Angew. Chem. 2019https://doi.org/10.1002/anie.201903134


Considerations on probe design for affinity guided protein conjugation Mortensen, M. R.; Skovsgaard, M. B.; Gothelf, K. V. ChemBioChem 2019https://doi.org/10.1002/cbic.201900157


Affinity-Guided Conjugation to Antibodies for use in Positron Emission Tomography Skovsgaard, M. B.; Jeppesen, T. E.; Mortensen, M. R.; Nielsen, C. H.; Madsen, J.; Kjær, A.; Gothelf, K. V. Bioconjugate Chem.2019, 30, 881-887, https://doi.org/10.1021/acs.bioconjchem.9b00013


Chemistries for DNA Nanotechnology Madsen, M; Gothelf, K.V. Chem. Rev. 2019https://doi.org/10.1021/acs.chemrev.8b00570


Imidazole Carbamate Probes for Affinity Guided Azide-Transfer to Metal-Binding Protein Mortensen, M. R.; Nielsen, N. L.; Palmfeldt, J.; Gothelf K. V. Org. Biomo.l Chem.201917, 1379-1383,https://doi.org/10.1039/c8ob03017k