Prof. Andriy Mokhir gives a Specialized iNANO Lecture on ‘Singlet oxygen – responsive bioconjugates for control of biochemical processes and detection of nucleic acids in vitro and in live cells‘ on Wed 15 June 2016 at 10:15 — 11:00 in iNANO aud (1593-012). Kurt Gothelf is the host of Prof. Andriy Mokhir’s visit in connection to the PhD-defence of Michael Vingborg Kjelstrup on Wed 15 June 2015 at 13:15 in Aud I (Dept. of Chemistry).

Title and abstract of prof. Andriy Mokhir’s lecture:

Singlet oxygen – responsive bioconjugates for control of biochemical processes and detection of nucleic acids in vitro and in live cells

Singlet oxygen (¹O₂) is a reactive molecule, which can be photogenerated from triplet oxygen in the presence of photosensitizers. In water lifetime of ¹O₂ is only 3.5 µs, which limits its sphere of action to several hundred nanometers. Therefore, the effect of this reagent is well localized after its generation that allows for many interesting biological applications. In particular, the group of Mokhir develops substrates/bioconjugates, which can release active biomolecules or fluorophores upon their reaction with ¹O₂. These substrates/bioconjugates are applied to control biochemical processes (e.g. RNA interference, RNAi) and to detect biomolecules (e.g. rRNA and mRNAs) in live cells [1-4]. These topics will be discussed during the presentation of A. Mokhir.

References:

[1] Pieper, H.; Chercheja, S.; Eigler, S.; Halbig, C.; Filipovic, M. R.; Mokhir, A. Angew. Chem. Int. Ed 2016, 55(1), 405-407.

[2] Meyer, A.; Mokhir, A. Angew. Chem. Int. Ed., (2014), 53(47), 12840-12843.

[3] Dutta, S.; Fülöp, A.; Mokhir, A., Bioconjugate Chemistry, (2013), 24(9), 1533-1542.

[4] Arian, D.; Kovbasyuk, L.; Mokhir, A., J. Am. Chem. Soc. (2011), 133(11), 3972-3980.