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2021


Qualifying exam Asger Givskov Jørgensen

PhD student Asger Givskov Jørgensen will have his qualifying exam (part A) on Wednesday the 27th of January. His progress report is entitled 'Analyzing food ingredients by a novel APTA-SHAPE technology' and the examiners are:

Senior R&D Manager Marie Stampe Ostenfeld, Arla Foods

Associate professor Ken Howard, iNANO, Aarhus University

Professor Jørgen Kjems, iNANO and Department of Molecular Biology and Genetics, Aarhus University

Assistant professor Daniel Miotto Dupont, iNANO, Aarhus University

To receive a link to the event, please send an e-mail to Asger Givskov Jørgensen, asgergivskov@inano.au.dk  


PhD position available in the Kjems lab

FRIDAY 15 JAN 2021

We currently have an opening for a PhD student in the Kjems lab. The application deadline is February 1st.

The project -  Multifunctional RNA nanostructures for imaging and therapeutic intervention  - aims to create multifunctional RNA-based nanostructures that can image, facilitate targeted delivery and act as gene medicine in diseased tissue with a special focus on cancer, inflammatory and viral diseases. The project will cover areas from conjugation chemistry, aptamer technology, molecular characterization, cell culture assay and testing in pre-clinical model systems. The aim of the project is to provide early diagnosis of disease progression and more effective delivery of drugs with minimal side-effects. The project is conducted in close synergy between multidisciplinary groups at iNANO and international clinicians.

This PhD project is part of the Center for Multifunctional Biomolecular Drug Design - CEMBID - funded by the Novo Nordisk Foundation. Based on interdisciplinary work in chemistry, molecular biology, pharmacology and medicine, CEMBID aims to develop new multifunctional biomolecular drugs, which will pave the way for new types of drugs that are more effective, have fewer side effects and can be adapted to the individual patient. 

A full description of the project and the conditions for applying can be found here https://phd.nat.au.dk/for-applicants/apply-here/february-2021/multifunctional-rna-nanostructures-for-imaging-and-therapeutic-intervention/

For more information, please contact Prof. Jørgen Kjems (jk@mbg.au.dk)

To apply for this position go to https://phd.nat.au.dk/for-applicants/apply-here/


Lundbeck Experiment grant to Julian Valero

THURSDAY 8 JANUARY 2021

Congratulations to assistant professor Julian Valero who was just awarded a two-year grant from the Lundbeck foundation for the project: Evolving new types of therapeutics - reshuffling old players in new ways

https://www.lundbeckfonden.com/lf-experiment-2020-lundbeckfonden/


2020


Identifying new biomarkers for liver disease

TUESDAY DEC 15 2020

A new collaborative project between the Kjems lab and Henning Grønbæk's research group at Aarhus University Hospital has received funding through ODIN, a new open-science initiative supported by the Novo Nordisk Foundation (https://projects.au.dk/odin/)

The project aims to identify novel biomarkers in blood from NAFLD (non-alcoholic fatty liver disease) and NASH (non-alcoholic steatohepatitis) patients using APTASHAPE, a high-throughput, unbiased screening method based on RNA aptamers. By following changes biomolecule composition in the blood during onset, development and treatment of disease the research team hopes to identify biomarkers that can diagnose and stage patients and monitor treatment response without the need for invasive liver biopsies.

Read more about ODIN and the project here: https://nat.au.dk/en/about-the-faculty/news/show/artikel/aarhus-university-and-industry-start-five-open-research-projects-to-pave-the-way-for-new-pharmaceuti/  


PhD defence - I-Ju Lo

MONDAY 19th of October 2020

Thesis title: Functional genomic insights of circRNAs in Alzheimer’s disease

Circular RNA, a non-coding RNA family enriched in the human brain, has attracted attention by its aging-related biological features and potential clinical applications in neurodegenerative diseases. During her Ph.D. studies, I-Ju Lo focused on the role of circRNAs in multiple Alzheimer’s disease-related brain regions. Integrating the genetics and transcriptomic data, I-Ju Lo identified tissue-specific circRNA changes associated with Alzheimer’s disease severity and discovered the genetic regulation of circRNAs in the disease.

Her results reveal the circRNAs as functional molecules in Alzheimer’s disease and the interaction between genetics and circRNAs. The potential of circRNAs as functional intermediates can help to link the genetic influence to the pathological mechanism.

The PhD study was completed at Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University.


Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds

TUESDAY 3 NOVEMBER 2020

A new paper from Marjan, Veronica and Jesper shows that aptamers can be multimerised on RNA-nanoscaffolds, leading to increased binding affinity to cancer-relevant target proteins. The full paper can be found here: https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(20)30325-5


New paper on how tissue-specific expression of the circular RNA ciRS-7 questions its suggested role in cancer

New imaging data reveals that a cancer-related circRNA is not expressed in tumor cells but in the flanking tissue

MONDAY 21 SEPTEMBER 2020

In a collaboration between Jørgen Kjems' lab at iNANO, Lasse Sommer Kristensen's lab at Biomedicine and Henrik Hager's group at Lillebælt Hospital we were able to show that the circRNA ciRS-7, reported to have an oncogenic role in various cancer types, is actually not present in tumour cells. Instead, ciRS-7 expression is mainly seen in the surrounding stroma. This finding stresses the need to look at cell- and tissue-specific expression when defining cancer biomarkers and oncogenic drivers - and questions the prevalent model for how changes in ciRS-7 levels relate to tumour development. 

Kristensen LS, Ebbesen KK, Sokol M, Jakobsen T, Korsgaard U, Eriksen AC, Hansen TB, Kjems J & Hager H. Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory. Nature Communications volume 11, Article number: 4551 (2020) https://doi.org/10.1038/s41467-020-18355-2

Link to a longer news story at the Department of Molecular Biology and Genetics (in English and Danish) 

Link to a newspaper article (in Danish) about the finding and the implications for cancer research. 


Master's defence - Josefine Bager Madsen

WEDNESDAY 2 SEPTEMBER 2020

Thesis title: LNA self-assembled Holliday Junction as a platform for nanoscaled theranostics against the somatostatin receptor 2

Josefine Bager Madsen from the Kjems lab will defend her Master's thesis on Friday, the 11th of September at 13.15. The defence will take place in room 1590-213 at iNANO and also be available as an online meeting via Zoom


New research collaboration will develop nano shells that encapsulate and fight virus particles

Virofight will develop shell-forming nanoparticles that enclose and neutralize viruses. (Ill.: Hendrik Dietz, Technical University of Munich)

TUESDAY 13 JULY 2020

The Kjems lab is part of Virofight, a new research consortium that has received funding from the EU FET-OPEN program to advance novel antiviral treatment. Instead of targeting virus-specific proteins or enzymes by small molecules as done by current antivirals, the Virofight project will develop DNA-based nano-shells that engulf and neutralize entire viruses. This novel approach has the potential to help fight multiple viruses with one generic approach.

Viral infections affect millions of people every year and cause tremendous human suffering and costs to society. For the majority of all WHO-listed viruses, there is no treatment available and the antiviral drugs that do exist must be applied very early after infection to be effective. The Virofight consortium proposes a new approach to fight viral infections, addressing the lack of broadly applicable antiviral treatments and creating means for combating new viral diseases. The consortium consists of five research groups in Germany, Slovenia and Denmark and is coordinated by Hendrik Dietz at the Technical University of Munich.

Virofight is supported by the European Union’s Horizon 2020 funding program with 3.88 million Euro. The project was initiated on 1st June 2020 and will run for four years.

Read the official press release by Virofight here.


PhD position available in the Kjems lab

FRIDAY 10 JULY 2020

We currently have an opening for a PhD student in the Kjems lab. The PhD project is part of the Center for Multifunctional Biomolecular Drug Design - CEMBID - funded by the Novo Nordisk Foundation (www.CEMBID.au.dk) and the workplace will be at iNANO at Aarhus University. The application deadline is August 1st, the earliest starting date is November 1st.

The project -  Bioimaging and disease treatment using bioconjugated, multifunctional compounds  - is focused on creating multifunctional nanomedicine through rational design and screening analysis in cells and animal models. This will be accomplished by tethering targeting molecules (antibodies, nanobodies, receptor ligands, aptamers) with imaging tracers (fluorescence molecules and radioisotopes for PET imaging) and drugs (toxins, antisense, RNAi, CRISPR/Cas) via advanced bioconjugation chemistry for subsequent testing. The main focus points are imaging and treatment of cancer, inflammation and viral infections (influenza and SARS-CoV2). The project is conducted in close synergy between multidisciplinary groups at iNANO and clinicians.

A full description of the project and the conditions for applying can be found here https://phd.nat.au.dk/for-applicants/apply-here/august-2020/bioimaging-and-disease-treatment-using-bioconjugated-multifunctional-compounds/

For more information, please contact Prof. Jørgen Kjems (jk@mbg.au.dk)

To apply for this position go to https://phd.nat.au.dk/for-applicants/apply-here/


IJu's paper is out in RNA biology: circRNAs as biomarkers for Alzheimer's Disease

MONDAY 6 JULY

In a new paper, IJu Lo - bioinformatics PhD student in the Kjems lab - analysed RNA-sequencing data from a cohort of Alzheimer's disease patients and found that circRNA expression patterns in specific brain regions differ between patients at different stages of disease severity and the healthy controls. This finding provides a basis for future functional studies to get a better understanding of disease development and could be used as a biomarker set for early screening and diagnosis of AD patients. 

IJu is enrolled as an industry PhD student and the study was performed in collaboration with the company Qiagen.

The paper 'Linking the association between circRNAs and Alzheimer’s disease progression by multi-tissue circular RNA characterization' by IJu Lo, Jamie Hill, Bjarni J. Vilhjálmsson and Jørgen Kjems can be found here https://www.tandfonline.com/doi/full/10.1080/15476286.2020.1783487


Large-scale data sets identify small RNAs with a role in epilepsy

Jørgen Kjems and Morten T Venø

THURSDAY 25 JUNE 2020

A new paper from Jørgen Kjems' group at iNANO and MBG describes how expression of non-coding RNA changes during epileptic seizures in rodents. The authors found that inhibiting a specific set of microRNAs (miRNAs) by antisense technology reduced seizure frequency in a mouse model, suggesting that these RNA molecules could serve as possible targets for future epilepsy therapy.

The work, published in the journal PNAS, was spear-headed by former MBG/INANO-postdoc Morten Venø - now the CEO of AU spin-off company Omiics - and performed in close collaboration with the EU-funded consortium EpimiRNA. The consortium provided state-of-the-art animal models for epilepsy, which were analysed for disease-relevant RNA-expression by the Kjems lab. 

Epilepsy is a neurological disorder characterised by recurrent epileptic seizures and it displays a wide range in severity (from mild to highly debilitating) and in susceptibility to treatment. Temporal lobe epilepsy (TLE) is a type of epilepsy characterized by seizures that arise from the hippocampus. Many TLE patients do not respond to drug treatment, often necessitating surgical resection of the brain structures affected. Jørgen Kjems and co-workers extracted brain tissue from three different rodent epilepsy models before and after the onset of epileptic seizures and used Next Generation Sequencing to map changes in expression of small non-coding RNAs. A set of miRNAs was found to respond to seizures in a similar manner in all three animal models, suggesting a general role in epilepsyrather than a species-specific effect. The authors went on to show that inhibition of these epilepsy-regulated miRNAsupon injection of antisense RNA strands reduced the rate of spontaneous seizures in a mouse model. While the underlying molecular mechanism behind this effect remains unclear, bioinformatics and proteomics work suggested the TGFβ signaling pathway to be involved.

The study is a result of more than four years of work in different labs in EpimiRNA and the authors hope that the large amount of sequencing data generated can serve as a resource for future studies on the molecular basis for epilepsy. The paper 'A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy' is published in the journal Proceedings of the National Academy of Sciences (PNAS).

https://www.pnas.org/content/early/2020/06/23/1919313117


PhD defence - Søren Fjelstrup

PhD student Søren Fjelstrup

MONDAY 29th of June 2020

Thesis title: Aptamer Fishing in Complex Sequence Pools

During his PhD studies, Søren Fjelstrup researched characterization of complex biological samples using aptamer libraries. The sensation of taste is produced by innumerable different chemical compounds which are recognized by taste receptors. By producing artificial receptor analogs, we can rival this wide specificity. This allows us to detect complex changes in the body, in which a single measurement is not sufficient. An example of this would be cancer. Using machine learning algorithms, it has been shown in this work that it is possible to translate the signals from millions of these receptor analogs in a way that allows detection of bladder cancer in blood and to distinguish between different beers.

The PhD study was completed at Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University.


The Kjems lab receives several grants for COVID-19 research

APRIL 2020

In response to the COVID-19 pandemic, public and private Danish foundations have decided to support projects that offer a deeper understanding of SARS-CoV-2 detection, behaviour, biology and therapy. Two projects in the lab - both utilising the versatility and precision of RNA aptamers - have been launched as a result.

The first project is supported by a Semper Ardens grant from the Carlsberg foundation. The goal is to develop a diagnostic test and alternative treatment options based on new aptamer technologies. Professor Jørgen Kjems from iNANO and the Department of Molecular Biology and Genetics leads the group of AU researchers participating in the project:

“I look forward to starting this project as soon as possible, which is the result of the serious situation in Denmark. We are joining together across many disciplines to solve these tasks with completely new innovative methods. Although we may be late for the current epidemic, I am convinced that, with this research effort, we will be much stronger next time virus ravages the world,” he says.

“For a virus to take over the control of our cells, it must pass through the cell membrane, and this is precisely this initial step in the infection process that we want to block. To that end, we have developed a new type of aptamer, that is, small DNA-like molecules comparable to antibodies. They can be designed to specifically bind all proteins on the surface of the corona virus, giving hope that the drug will also be active against future coronaviruses.”, says Jørgen Kjems.

Read the announcement from the Carlsberg foundation here:

'Stay curious' video explaining the project (in Danish):  

https://www.carlsbergfondet.dk/da/Nyheder/Nyt-fra-fondet/Nyheder/Hvordan-bekaemper-forskerne-COVID19 

The other project is supported by the Independent Research Fund and is carried out in collaboration with researchers at Rigshospitalet in Copenhagen and the Danish Technical University. Here the focus is to use the so-called 'APTASHAPE' technology, where billions of small biosensor molecules, based on RNA, provide a snapshot of proteins and metabolites in the patient's blood. The ultimate goal of the technology is to create a fast screening platform that can reveal if a person has been infected within a few days and at the same time warn of any complications due to their underlying disease status.

The announcement from the Independent Research Fund Denmark can be found here


News 2019

Liviu's paper is out in time for Christmas - congratulations!

WEDNESDAY 18 DECEMBER 2019

In a new paper from the lab, PhD student Liviu-Ionut Moldovan maps circRNA expression patterns in psoriasis and discusses how reduced circRNA levels in lesional skins may function as biomarkers or potentially contribute to disease development.

Read the full paper here: https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-019-0616-2

Moldovan, L.I., Hansen, T.B., Venø, M.T., Okholm, T.L.H., Andersen, T.L., Hager, H., Iversen, L., Kjems, J., Johansen, C., Kristensen, L.S.: High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome. BMC Med Genomics. 2019 Nov 27;12(1):174


New paper published - congratulations Rasmus!

MONDAY 16 DECEMBER 2019

The results from Rasmus Thomsen's PhD work in the lab are now published in a paper in Nature Communications. Using DNA origami, Rasmus and colleagues in Aarhus, Copenhagen and Germany created a large synthetic nanopore made from DNA. This nanopore structure is capable of translocating large protein-sized macromolecules between compartments separated by a lipid bilayer. In addition, a functional gating system was introduced inside the pore to enable biosensing of very few molecules in solution. 

With the use of powerful optical microscopes, the researchers could follow the flow of molecules through individual nanopores. By introducing a controllable plug in the pore, it was furthermore possible to size-selectively control the flow of protein-size molecules and demonstrate label-free, real time, bio-sensing of a trigger molecule. 

Lastly the pore was equipped with a set of controllable flaps, allowing targeted insertion into membranes displaying particular signal molecules. In the future, this mechanism will potentially enable insertion of the sensor specifically into diseased cells and may allow diagnosis at the single cell level.

Thomsen, R.P., Malle, M.G., Okholm, A.H., Krishnan, S., Bohr, S.S.-R., Sørensen, R.S., Ries, O., Vogel, S., Simmel, F.C., Hatzakis, N.S., Kjems, J.: A large size-selective DNA nanopore with sensing applications. Nature Communications volume 10, 5655 (2019) https://www.nature.com/articles/s41467-019-13284-1


New paper published - congratulations Veronica!

FRIDAY 10 MAY 2019

Nucleic acids provide a versatile, programmable scaffold that allows the construction of highly functionalised molecules. This is illustrated in a recent paper from the lab, A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine, published in the journal Theranostics. In this paper, the authors show that specifically designed RNA oligos can form a stable Holliday Junction - inspired by the four-stranded DNA structures that appear during DNA recombination and repair - that allows the attachment of four different functionalities on extended RNA strands. 

Andersen, V. L., Vinther, M., Kumar, R., Ries, A., Wengel, J., Nielsen, J. S. & Kjems, J. (2019). A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine. Theranostics, 9(9), 2662-2677. https://doi.org/10.7150/thno.32060


PhD position available in the Kjems lab

MONDAY 15 APRIL 2019

We currently have an opening for a PhD student in the Kjems lab. The position is funded via the DNRF center CellPAT (www.CellPAT.au.dk) and the workplace will be at iNANO at Aarhus University. The application deadline is May 1st, the earliest starting date is Aug 1st.

The project - Interfacing cells functionally with multivalent, patterned signals - involves molecular design of self-assembled DNA and RNA scaffolds that display functional ligands for cellular uptake, differentiation and immune response, with a particular focus on understanding the importance of spatial organization and multivalency of the ligands. The complexes are investigated functionally in cell-free systems, in cells and eventually in animal models. The main methodologies applied in the PhD study are nucleic acid-based structural design at chemical and molecular level, molecular binding assays, in vitro evolution methods, structure and binding characterization by various biophysical methods and functional implications on cells by flow cytometry, RNA expression profiling, and super-resolution microscopy.

For more information, please contact Prof. Jørgen Kjems (jk@mbg.au.dk)


New paper from the Kjems lab

MONDAY 8 APRIL 2019

The Journal of Visualised Experiments (JoVE) challenges the traditional format for research articles by publishing high-quality instruction videos for protocols and new discoveries. A cross-collaborative effort between the two halves of the Kjems lab - involving postdocs and PhD students from both iNANO and MBG - recently led to the publication of a video article in JoVE. The video describes the isolation, sequencing and analysis of extracellular microRNAs from human mesenchymal stem cells.

The full video (and a pdf version of the transcript and protocol) can be found here https://www.jove.com/video/58655/isolating-sequencing-analyzing-extracellular-micrornas-from-human

Yan, Y., Chang, C. C., Venø, M. T., Mothershead, C. R., Su, J. & Kjems, J. (2019). Isolating, Sequencing and Analyzing Extracellular MicroRNAs from Human Mesenchymal Stem Cells. Journal of visualized experiments: JoVE, (145), [e58655].


circRTrain PhD course in Aarhus

WEDNESDAY 20 MARCH 2019

We recently hosted 15 PhD students from the circRTrain network (https://circrtrain.eu) for a course held at iNANO/MBG on the 11-14th of March. The course was focused on theoretical and practical training in using Nanopore and Nanostring technology for the sequencing and quantification of RNA.


Qualifying exam I-Ju Lo

PhD student I-Ju Lo will have her qualifying exam (del A) on Tuesday the 29th of January. Her progress report is entitled 'Discovering circular RNAs as a biomarker in Alzheimer’s disease with the functional genomics approach' and the examiners are:

Professor Albin Sandelin, Department of Biology, University of Copenhagen

Professor Troels Skrydstrup, iNANO and Department of Chemistry, Aarhus University

Professor Jørgen Kjems, iNANO and Department of Molecular Biology and Genetics, Aarhus University

Mr. Jamie Hill, Qiagen 


Two PhD positions available in the Kjems lab - application deadline 1st of February 2019

MONDAY 14 JANUARY 2019


The Kjems lab invites applications for two PhD fellowships at the Graduate School of Science and Technology (GSST), Aarhus University, within the Nanoscience programme.  http://phd.scitech.au.dk 

The first PhD project focuses on the use of a new technology, DNASHAPE, to analyse food ingredients and detect contaminants and pathogens, while the other one uses nucleic acids, protein, lipids and sugars as building blocks for the construction of novel functional nanomachines.

More information about the projects and how to apply can be found here

phd.scitech.au.dk/for-applicants/apply-here/february-2019/analyzing-food-ingredients-by-a-novel-dnashape-technology/  (Call closed)

phd.scitech.au.dk/for-applicants/apply-here/february-2019/building-novel-functional-nanomachines-from-nucleic-acids-protein-lipids-and-sugars/  (Call closed)


News 2018

PhD defence - Veronica Liv Andersen

PhD student Veronica Liv Andersen

THURSDAY 22 NOVEMBER 2018

Thesis title: Self-assembled nanoscaffolds for personalized medicine

Traditional methods for diagnostics and therapy for diseases such as cancer are often imprecise and can therefore be both ineffective and cause severe side effects. In her PhD studies, Veronica Liv Andersen has developed self-assembled nanostructures that can be used to form multifunctional therapeutic systems. By utilizing chemically modified nucleic acids that are structurally and functionally similar to DNA and RNA as building blocks for the scaffold itself, highly well-defined and biocompatible structures can be designed. The design principle investigated in these studies relies on the the production of a number of different functional modules that subsequently can be assembled and combined - much like LEGO bricks - to form a structure that carries exactly the set of therapeutic molecules that are effective in a specific disease in the individual patient. These results thereby contribute new perspectives and methods to the field of personalized medicine and theranostics, the combination of precision therapy and diagnostics.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.


PhD defence - Rasmus Peter Thomsen

PhD student Rasmus Peter Thomsen

WEDNESDAY 14 NOVEMBER 2018

Thesis title: Engineering Peptides, Proteins, and Lipid Membranes with DNA Nanotechnology

The ability to engineer, control, and manipulate molecular assemblies is emerging and one approach to do so involves the use of DNA nanostructures and designs. This approach has evolved immensely since its inception more than 35 years ago. During his studies, Rasmus has designed, developed, and used DNA nanotechnology to engineer peptides, proteins, and lipid membranes. Common to all projects are the use of DNA as a structural scaffold, modified chemically and enzymatically with functional probes. The systems have been uniquely designed towards a desired purpose. Put together, the results demonstrate the versatility and modularity of DNA nanotechnology, which can serve as a nanoscale engineering tool by providing a programmable scaffold.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University. 


AU Professor awarded the Novo Nordisk Prize 2018

Professor Jørgen Kjems is Director of iNANO and will now also be Director of the Centre for Cellular Signal Patterns.

Professor at Department of Molecular Biology and Genetics and iNANO Jørgen Kjems is receiving the 2018 Novo Nordisk Prize for his pioneering interdisciplinary studies of how RNA, the biological cousin of DNA, plays a key role in regulating cells and has enormous future potential in treating disease. The Novo Nordisk Foundation awards the Prize, which is accompanied by DKK 3 million.

2018.01.31 | CHRISTIAN MOSTRUP SCHEEL OG CHRISTINA TROELSEN

Jørgen Kjems’ scientific activities have always been technically and conceptually innovative. He contributed to challenging a key dogma within human biology early in his career when he and colleagues discovered that RNA has several unexpected key functions in relation to human genes.

At that time, most researchers thought that RNA simply functioned as a messenger between DNA and cellular proteins. “We helped to demonstrate that, in addition to transporting genetic information, RNA also acts as a key regulator of various cell processes. Since then, it has been shown that up to 90% of all RNA probably has other key functions, such as regulating human genes,” says Jørgen Kjems.

Among the many important new scientific breakthroughs to which Jørgen Kjems’ group has contributed, a crucial one was the discovery in 2011 that circular RNA is highly prevalent in most organisms, including people. Circular RNA has a very important role in regulating other genes in the body. In 2013, the research group confirmed in an article published in Nature that circular RNA functions as a kind of sponge that absorbs other RNA molecules and proteins so that they do not affect cellular metabolism. The more than 10,000 types of circular RNA therefore strongly influence the body’s regulatory mechanisms and are therefore also essential in diagnosing, preventing and treating for instance cancer and neurodegenerative diseases.

Jørgen Kjems is receiving the 2018 Novo Nordisk Prize for his outstanding research efforts. The Prize is awarded to recognize unique medical research or other research contributions that benefit medical science. The Novo Nordisk Foundation awards the Prize, which is accompanied by DKK 3 million.

“I am extremely honoured and very surprised to receive the Prize. I am grateful for the recognition of the importance of interdisciplinarity and wide-ranging vision that enables researchers to carry out both basic research and applied research within medicine. I consider this Prize as recognizing not just my research but also that of my colleagues,” says Jørgen Kjems.

Jørgen Frøkiær, Chair of the Novo Nordisk Prize Committee, says, “Throughout his career, Jørgen Kjems has conducted comprehensive, systematic and very original research that has produced pioneering new research on RNA and related fields. The numerous scientific results Jørgen Kjems has achieved through an interdisciplinary approach are both impressive and outstanding. Jørgen Kjems is a very worthy recipient of the 2018 Novo Nordisk Prize.”

Jørgen Kjems has been Professor of Molecular Biology and Nanoscience at Aarhus University since 2003. In 2013, he was appointed Director of the Interdisciplinary Nanoscience Center (iNANO) at Aarhus University, which integrates physics, chemistry, biology and medicine. In 2017, Jørgen Kjems was further appointed Director of CellPAT (Centre for Cellular Cell Patterns), funded by the Danish National Research Foundation. CellPAT aims to identify how cells talk to each other and thereby enable the types of communication errors that lead to disease to be prevented or corrected.


News 2014-2017

New centre will decipher the language of cells

Professor Jørgen Kjems is Director of iNANO and will now also be Director of the Centre for Cellular Signal Patterns.

A new basic research centre – CellPAT – will identify how cells ‘talk’ to each other, and thereby make it possible to prevent or correct the type of communication errors that lead to illness.

2017.04.20 | PETER F. GAMMELBY 

Everyone is familiar with the situation where you are about to pay in the supermarket, but have forgotten the PIN code. In this case, the brain searches for clues such as pattern recognition – where do you normally move your fingers, in which order, and how many times do you press each button? The cells in the human body communicate in the same way, only at a molecular level. And just as in the macroscopic world, even small communication errors can cause major problems. When errors occur in cellular communication, the entire organism can become ill. The new Centre for Cellular Signal Patterns (CellPAT) will therefore address fundamental questions in biology to identify how cells ‘talk’ to each other and their surroundings. The Danish National Research Foundation has just decided to provide CellPAT with funds amounting to up to DKK 61 million. The aim is to use advanced nanotechnology to create results that can be ground-breaking in the battle against some of the major health challenges we are facing today – such as diabetes, cancer, osteoporosis, arthritis and certain psychiatric disorders.

Complicated language requires advanced equipment Professor Jørgen Kjems, Aarhus University, takes his point of departure in the fact that the cells communicate through a network of weak interactions that together provide the necessary effect. “The old assumption that cellular macromolecules recognise each other like a key in a lock is not sufficient. On the contrary, the cell communicates by means of complex signals, where the number and particularly the pattern of contact points play an incredibly major role. Until now, the complexity of this interaction has made scientific studies difficult. Using completely new synthesis and analysis methods, however, we can produce and analyse the signals ourselves at CellPAT,” says Professor Kjems, director of the new centre.

The centre will focus in particular on how our immune cells can recognise the difference between external dangers and ourselves, and why this mechanism sometimes goes wrong and gives rise to autoimmune diseases such as arthritis, sclerosis and diabetes. The centre will also study the way macromolecules are transported through biological barriers in the body, such as the blood-brain barrier and cell membranes. This knowledge will form the basis for developing more targeted and effective drugs with fewer side effects. In addition, the centre will study which signals the stem cells need to receive in order to develop into specific types of tissue in the body. This knowledge will create an opportunity to use stem cells to re-establish tissue in the body when the old cells are destroyed by a poor lifestyle, disease or injury. It is thought that the method will eventually be used to regenerate human organs.

Professor Kjems is a very experienced research director and one of the leading international profiles in DNA and RNA nanotechnology, where he is particularly recognised for having moved the research front in self-assembling systems in DNA, intracellular circular RNA and genetic medicine. He has been the director of the Interdisciplinary Nanoscience Centre (iNANO) at Aarhus University for four years.

Participating at the centre are Professor Duncan Sutherland, iNANO, Aarhus University Professor Steffen Thiel, Department of Biomedicine, Aarhus University Professor Fiona Watt, King’s College London, UK Group Leader Dr Ralf Jungmann, Ludwig-Maximilians-Universität Munich (LMU) and Max Plank Institute of Biochemistry (MPIB) Munich, Germany


Semper Ardens Grant to Jørgen Kjems

Director & professor Jørgen Kjems

The Carlsberg Foundation has just awarded ten Semper Ardens grants for a total sum of 117 million DKK.

2016.05.12 | TRINE MØLLER HANSEN

Aarhus University receives six grants of which four go to ST, one of these goes to Jørgen Kjems. In the DNA-SHAPE project, the researchers will develop a new method which will make it possible to "translate" the total content in a specific food to digitized information in the form of DNA sequences. From advanced computer analysis of DNA sequences it will be possible to obtain a digital fingerprint of the food content, which potentially can be used as a marker for food quality, safety and authenticity. Grant recipient: Professor Jørgen Kjems, iNANO
Project: Analysis of complex biological mixtures by a novel method: ”DNA-shapes” Grant:6,1 million DKK Project period: 3 years


picture of Professor Jørgen Kjems, Director of iNANO
Professor Jørgen Kjems, the new director of iNANO.

Head of LUNA Prof. Jørgen Kjems Appointed Director of iNANO

Acting Director since 2014

2015.01.21 | Rebeca Suarez Alvarez Thostrup

Professor Jørgen Kjems, the new director of iNANO. Photo: Lars Kruse, AU Communication

Professor Jørgen Kjems has been appointed director of the Interdisciplinary Nanoscience Centre (iNANO) for a three-year period. He has been an integrated part of the management at the centre for a number of years, both as a founding member of iNANO and as acting director since 2014.

Professor Kjems studied at Aarhus University, where he completed his PhD in Biostructural Chemistry in 1989 at the Department of Chemistry. He subsequently spent three years as a postdoctoral fellow at Harvard and the Massachusetts Institute of Technology (MIT) in Cambridge, USA, prior to returning to Aarhus. He was appointed associate professor at the Department of Molecular Biology and Genetics in 1994 and professor in 2003.

With a main field of research in nanomedicine, Professor Kjems has over the years contributed with world-class research in this area, and he has built up a large international network. He has published approximately 250 scientific articles and has 10,000 citations. His latest major discovery, which was published in Nature in 2013, is the presence of a new type of circular RNA molecules in human cells that can be used as both disease markers and nanomedicine.

Professor Kjems is also principal investigator (PI) of the LUNA Centre (the Lundbeck Foundation Nanomedicine Centre for Individualized Management of Tissue Damage and Regeneration), and he participates in a number of other centres – the Centre for DNA Nanotechnology (CDNA), the Biomolecular Nanoscale Engineering Centre (BioNEC) and Aarhus University’s Centre for Integrative Sequencing (iSEQ).

Over the years, Professor Kjems has received a number of awards, and he is a member of several academic councils.

He was born in 1959 and is married to Lena, a minister of religion in Vejlby. They have three children and live in the Aarhus suburb of Risskov.

For more information, please contact

Professor Jørgen Kjems
Director of iNANO
Aarhus University
Mobile +45 2899 2086
kjems@inano.au.dk

Article by Anne- Mette Siem