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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Alexander Zelikin and Kim Daasbjerg are among this year's recipients of VILLUM Experiment grants. (Photos: Lars Kruse, AU Photo)

2020.09.15 | iNano

Grants for wild ideas

VILLUM Experiment has just awarded grants to Danish researchers, who each represent innovative approaches to their research areas, and thus to test their brave and strange technical and scientific research ideas. Associate Professor Alexander Zelikin and Professor Kim Daasbjerg are among the recipients.

Professor Jørgen Kjems represents the Danish node of the LifeTime Initiative, which includes more than 50 European Universities. A new Perspective article in Nature outlines LifeTime's vision of how to improve healthcare through cell-based medicine. (Photo: Jesper Rais, AU Photo)

2020.09.09 | iNano

International initiative seeks to improve healthcare through cell-based medicine

The research initiative LifeTime represents more than 50 European universities, including Aarhus University. A new Perspective article in Nature, co-authored by Jørgen Kjems from iNANO and Department of Molecular Biology and Genetics, outlines LifeTime's vision of how to revolutionize healthcare through personalised, cell-based interceptive…

Associate Professor Frans Mulder and coworkers at Aarhus University have developed ODiNPred (Prediction of Order and Disorder by evaluation of NMR data), a software tool developed for prediction of protein order and disorder. (Image: Frans Mulder)

2020.09.08 | iNano

Prediction of protein disorder from amino acid sequence

Structural disorder is vital for proteins’ function in diverse biological processes. It is therefore highly desirable to be able to predict the degree of order and disorder from amino acid sequence. AU researchers have developed a prediction tool by using machine learning together with experimental NMR data for hundreds of proteins, which is…

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