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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

A project team from Aarhus University and Fida Biosystems will use advanced microfluidic techniques in the search for compounds, which can block the contact between SARS-CoV-2 virus and receptors on human cells. Click on the graphic to see it full size. (Graphics by Daniel Otzen)
Daniel Otzen is heading a collaborative project with DKK 3.8 million from the Innovation Fund Denmark for combating COVID-19. Photo: Jesper Rais, AU.

2020.05.29 | iNano

DKK 3.8 million for collaboration on fighting COVID-19

Daniel Otzen and collaborators, Jørgen Kjems and Victoria Birkedal from the Interdisciplinary Nanoscience Center (iNANO) and the company Fida Biosystems, have received DKK 3.8 million from the Innovation Fund Denmark to develop a screening system to identify drugs that are able to combat COVID-19.

Alexander Zelikin, Birgit Schiøtt, Frans Mulder and Jørgen Skibsted receive DKK 21,4 million in total from Independent Research Fund Denmark. Photos: Lars Kruse (AU Photo) and private.

2020.05.19 | iNano

4 researchers from iNANO and Department of Chemistry receive DKK 21.4m in total

Alexander Zelikin, Birgit Schiøtt, Frans Mulder and Jørgen Skibsted are among 59 AU researchers who have been successful in the recent call by the Independent Research Fund Denmark. In total the 4 researchers have received DKK 21.4 million.

“An intravital microscopy image depicting blood vessels, macrophages and nanoparticles. Interested in how they move in real-time? See the movie featured at the end of this article (image: Yuya Hayashi)

2020.05.13 | iNano

Zebrafish let you see the biological fate of nanoparticles in vivo

Ever wondered if you could see through the body of a living organism and observe the dynamic interplay between cells and nanoparticles injected into the bloodstream? Pia Bombolt and Thomas Boesen contribute to research published in ACS Nano showing how the use of transgenic zebrafish embryos now offers a unique opportunity for intravital…

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