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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Virofight will develop shell-forming nanoparticles that enclose and neutralize viruses. (Ill.: Hendrik Dietz, Technical University of Munich)
Virofight is supported by the European Union’s Horizon 2020 funding program with 3.88 million Euro.

2020.07.13 | iNano

New research collaboration will develop nano shells that encapsulate and fight virus particles

Professor Jørgen Kjems and the consortium Virofight has received funding from the EU FET-OPEN program to advance novel antiviral treatment. Instead of targeting virus-specific proteins or enzymes by small molecules as done by current antivirals, the Virofight project will develop DNA-based nano-shells that engulf and neutralize entire viruses.…

Ebbe S. Andersen receives 10 mio from the Novo Nordisk Foundation. (Photo: Lars Kruse, AU Photo)
Researchers from the Andersen Lab for Biomolecular Design who developed the RNA-based technology platform. (Photo: Nestor Sampedro)
Illustration of (A) RNA origami scaffolds that can be produced in cells, (B) RNA scaffolds for enzymatic cascades, (C) Function of RNA scaffolds and sensors in cells. (Ill.: Ebbe S. Andersen)

2020.07.03 | iNano

DKK 10 million for developing nanoscale assembly lines for biotechnological production

Ebbe S. Andersen is awarded a DKK 10 million Ascending Investigator Grant from the Novo Nordisk Foundation’s Research Leader Programme. The research project aims at using recently developed RNA nanotechnology-based assembly lines, sensors and nanorobots to improve biochemical reactions inside cells. The potential outcome will be improved bacterial…

Alexander Zelikin receives 13.5m from Novo Nordisk Foundation for signalling and internalising receptor mimics. (Photo: Lars Kruse, AU Photo)

2020.06.25 | iNano

The Novo Nordisk Foundation supports wild scientific and technical research ideas

For the first time, the Novo Nordisk Foundation has awarded grants within the research programme NERD, which is targeted at ambitious and wild research ideas in the fields of scientific and technical research. At Aarhus University, Associate Professor Alexander Zelikin has just received DKK 13.5 million.

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