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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Professors Jeppe Vang Lauritsen, Duncan Sutherland, and Professor Mogens Christensen each receive a share of DFF millions for green research ideas. (Illustr.: Colourbox)

2021.10.15 | iNano

3 iNANO researchers receive a share of green DFF millions

iNANO employees, Professors Jeppe Vang Lauritsen and Duncan Sutherland, and iNANO member, Professor Mogens Christensen, receive fundings from the Independent Research Fund Denmark. The researchers will study electrocatalytic hydrogen production, materials for building solar-thermal management, and compaction of Magnets, respectively.

The Danish Center for Ultrahigh Field NMR Spectroscopy at Aarhus University, with Professor Thomas Vosegaard in the front, is part of an EU funded 4-year and €5 million project. The aim is to integrate seven national infrastructures across Europe and provide efficient access to infrastructures in solid-state NMR available worldwide. (Photo: Maria Randima, AU Photo)

2021.10.12 | iNano

NMR Center part of new EU project: providing worldwide access to infrastructures in solid-state NMR

The use of solid-state NMR spectroscopy is pivotal in enabling the characterisation of structure and dynamics at the atomic-level. These methods rely on access to sophisticated and costly solid-state NMR equipment that is only available in few national facilities. The Danish Center for Ultrahigh Field NMR Spectroscopy at Aarhus University, with…

Professor Birgit Schiøtt. (Photo by Lars Kruse AU Photo)

2021.10.07 | iNano

New study capture sugar transport fundamental to plants

In a collaborative effort with Professor Birgit Schiøtt (iNANO member) and her research group, the researchers also used state-of-the-art Molecular Dynamics simulations to support the notion of proton binding employing multiple independent approaches.

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