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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Frans Mulder and his consortium, BOUNDLESS, has received DKK 14.4m from the Novo Nordisk Foundation. Besides Frans Mulder, the consortium consists of Lene N. Nejsum, and Magnus Kjærgaard from Aarhus University as well as Siewert Jan Marrink from University of Groningen (NL). (Photos: private)

2021.01.15 | iNano

New interdisciplinary consortium at AU will study membrane-less organelles

Associate Professor Frans Mulder is heading a new consortium, BOUNDLESS, funded by the Interdisciplinary Synergy Programme of the Novo Nordisk Foundation. With the grant the consortium will study how membrane-less organelles control key biological processes.

Henrik Birkedal interviewed to Politiken on mussel inspired leather adhesives. (Photo: Lise Balslev, AU Photo)

2021.01.06 | iNano

Mussels inspire new, green glue

Henrik Birkedal was interviewed to Danish national newspaper Politiken on his groups involvement in the development of mussel inspired leather adhesives, which occurs in a MUDP project funded by the Ministry of Environment of Denmark. (in Danish)

Aarhus University and industry start five open research projects to pave the way for new pharmaceuticals. (Photo: Ditte Høyer Engholm)

2020.12.16 | iNano

Aarhus University and industry start five open research projects to pave the way for new pharmaceuticals

Kidney diseases, atherosclerosis, colon cancer, non-alcoholic fatty liver disease and neurological disorders are five global health problems that the first five research projects in the Open Discovery Innovation Network (ODIN) are now addressing. In the projects, Ken Howard, Jørgen Kjems, and Daniel Otzen are among AU researchers and the…

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