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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Professor Jørgen Kjems and collaborators receive fundings from Independent Research Fund Denmark for corona related research. Photo: Jesper Rais, AU Photo

2020.04.24 | iNano

Fundings for prediction of COVID-19 infection and clinical severity

The healthcare system and the economy are under pressure in many parts of the world due to the ongoing COVID-19 pandemic. With fundings from Independent Research Fund Denmark Professor Jørgen Kjems will, in collaboration with researchers from DTU and Rigshospitalet, develop a method that can detect the virus at very early stages of infection and,…

Associate Professor Alexander publishes in Angewandte Chemie Int. Ed. on anticancer prodrug monotherapy. (Image: Copyright (2020) Angewandte Chemie Int. Ed.)

2020.04.24 | iNano

Zelikin laboratories publish new findings on potential anticancer prodrug monotherapy

Associate Professor Alexander Zelikin and his research team publish in Angewandte Chemie Int. Ed. on new results which makes tumor‐targeted glucuronides attractive for translational medicine.

Daniel Dupont is one of the very few who, exceptionally, has been granted access to his laboratory to develop means to combat coronavirus. Private photo.

2020.04.03 | iNano

Life with lockdown

Working and studying has been different in just as many ways as there are employees and students, and together, each in their own way, they are keeping the wheels of NAT running. Separately. Meet some of them here, including Daniel Dupont at iNANO.

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