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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

PhD student Jakob B. Grinderslev receives the Danscatt PhD award 2020 by Professor Bo Brummerstedt Iversen at the annual Danscatt meeting. (Private photo)

2020.08.21 | iNano

Danscatt PhD award 2020 goes to Jakob B. Grinderslev

Congratulations to Jakob B. Grinderslev who received this year's Danscatt PhD award for his PhD thesis about his work within boron and nitrogen based complex metal hydrides as energy storage materials.

Brigitte Städler receives the Danish polymer prize, Elastyrenprisen 2019 by the Danish Academy of Technical Sciences (ATV). (Photo: Jesper Rais, AU Photo)

2020.08.18 | iNano

Danish Academy of Technical Sciences awards prize to Brigitte Städler

Congratulations to Associate Professor Brigitte Städler who has been awarded the Danish Polymer Prize, the Elastyrene prize 2020, for her research in developing polymer-based nanomaterials for medical use. The award is given by the Danish Academy of Technical Sciences (ATV).

Virofight will develop shell-forming nanoparticles that enclose and neutralize viruses. (Ill.: Hendrik Dietz, Technical University of Munich)
Virofight is supported by the European Union’s Horizon 2020 funding program with 3.88 million Euro.

2020.07.13 | iNano

New research collaboration will develop nano shells that encapsulate and fight virus particles

Professor Jørgen Kjems and the consortium Virofight has received funding from the EU FET-OPEN program to advance novel antiviral treatment. Instead of targeting virus-specific proteins or enzymes by small molecules as done by current antivirals, the Virofight project will develop DNA-based nano-shells that engulf and neutralize entire viruses.…

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