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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  


A Danish research team describes in an article in Nature Communications how a well-described circular RNA molecule, which was thought to be carcinogenic, is not found in the cancer cells after all.

2020.09.21 | iNano

Well-known RNA molecule is not present in cancer cells after all

A so-called circular RNA molecule, which is thought to be carcinogenic, is not present in cancer cells after all. A Danish research team has published the new results in Nature Communications.

The state-of-the-art Danish National cryo-EM facilities, EMBION, will be inaugurated on October 12, 2020. The facilities are established by Aarhus University together with University of Copenhagen.
Professor Poul Nissen (Aarhus University) is leading EMBION, The Danish National Cryo-EM Facilities, together with Professor Guillermo Montoya (University of Copenhagen). (Photo: Lars Kruse, AU Photo)

2020.09.18 | iNano

Inauguration of the Danish National Cryo-EM Facility, EMBION

Cryogenic Electron Microscopy (cryo-EM) has become a truly important technique in molecular cell biology as well as medicine and biotechnology. Together with the University of Copenhagen, Aarhus University has established state-of-the-art cryo-EM facilities in Aarhus and Copenhagen, which will be inaugurated on October 12, 2020. The research…

Clouds play an important role for the amount of sunlight that reaches the surface of the Earth. An interdisciplinary team of researchers is studying what bioaerosols mean for the formation of ice in clouds. Photo: Colourbox

2020.09.18 | iNano

DKK 15 million from Novo for research in the clouds

The Novo Nordisk Foundation has granted DKK 15 million from its interdisciplinary synergy programme to project DRAMA. With researchers from both Nat and Tech, including Merete Bilde and Tobias Weidner, the project will decipher the role of atmospheric microbial aerosols for cloud formation.

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