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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Professor Birgit Schiøtt (Department of Chemistry and iNANO) receives a VILLUM Synergy grant of DKK 3.0 million together with Professor Ira Assent (Department of Computer Science). Photo: AU foto

2020.04.01 | iNano

There is synergy between computer science and chemistry

Professor Birgit Schiøtt (Department of Chemistry and iNANO) has received a VILLUM Synergy grant of DKK 3.0 million together with Professor Ira Assent (Department of Computer Science) for development of new cluster models that can provide a more accurate insight into proteins at the molecular level.

AU researchers collaborate with international research team on improving the efficiency of bioelectrical systems. (Graphics: Copyright © 2020, Nature Research).

2020.03.25 | iNano

Enhanced microbes as alternative green energy sources

The demand for energy is growing and so is the demand for alternative energy solutions, which includes living sources of electricity. AU researchers have in collaboration with an international team created microbial energy cells and shows a method for improving the efficiency of bioelectrical systems.

Professor Jørgen Kjems leads the group of AU researchers participating in the project. Photo: Peter F. Gammelby

2020.03.19 | iNano

AU steps up the virus research with millions from the Carlsberg Foundation

Professor Jørgen Kjems from MBG and iNANO will collaborate with researchers from Health, the University of Copenhagen and the Danish Serum Institute, and with DKK 25 millions from the Carlsberg Foundation they will develop methods for diagnosis, treatment and prevention of SARS-CoV-2 infections. The goal is at the same time to equip the world to…

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