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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Dorthe Bomholdt Ravnsbæk. Photo: Jacob Fredegaard Hansen, SDU

2021.06.22 | iNano

iNANO alumnus starts as new professor at Dept. of Chemistry in November

From 1 November, iNANO alumnus Dorthe Bomholdt Ravnsbæk will start a new position as professor and continue her research in rechargeable batteries at the Department of Chemistry.

Associate Professor Ebbe S. Andersen, Interdisciplinary Nanoscience Center (iNANO) at Aarhus University has received the Danish polymer Prize - ATV | Elastyrenprisen 2021. Chairman of the Prize committee Niels Chr. Nielsen also handed over the prize to Associate Professor Anders Egede Daugaard (DTU). Photo: Tom Jersø

2021.06.22 | iNano

Assoc. Prof. Ebbe S. Andersen honored by the Danish Academy of Technical Sciences

Congratulations to Associate Professor Ebbe S. Andersen who is awarded the Danish polymer prize, Elastyrenprisen 2021, for being an internationally recognized scientist and a pioneer within biopolymer research, including RNA origami. The award is given by the Danish Academy of Technical Sciences (ATV).

Professor Poul Nissen awarded Anders Jahre's major medical award in 2021 for his research in membrane proteins. Photo: Lisbeth Heilesen

2021.06.10 | iNano

Professor Poul Nissen awarded Anders Jahre's large medical award 2021

One of the Nordic region's most prestigious research prizes, the Anders Jahre Prize, goes to Professor Poul Nissen from Aarhus University. Poul Nissen is awarded the prize for his research in the transport of proteins in and out of cells. This knowledge is of great importance for understanding diseases such as cancer, cardiovascular disease and…

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