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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Associate Professor Alexander Zelikin is participating in EU project against corona virus. Photo: Lars Kruse, AU Photo

2020.03.19 | iNano

iNANO researcher involved in EU project against corona virus

Alexander Zelikin from iNANO and Department of Chemistry is key partner in the Fight-nCov project for developing antiviral treatment against corona virus.

From AU, researchers from the three faculties of Natural Sciences, Technical Sciences and Health participate in the ODIN network. Photo: Jesper Rais, AU Communication

2020.03.11 | iNano

Aarhus University and the pharmaceutical industry work together on open innovation - a shortcut to new medicines

Aarhus University and a number of international pharmaceutical manufacturers are joining forces in a groundbreaking, open research collaboration, ODIN (Open Discovery Innovation Network), which the Novo Nordisk Foundation supports with DKK 54.5 million. Data and results from the collaboration are made open and free to the outside world. The…

Controlled CO2 reduction to either CO or formic acid dependent on the catalyst design. (Graphics: Copyright © 2020, Journal of the American Chemical Society)
PhD Student Joakim B. Jakobsen, PhD Student Monica R. Madsen, and Post doc Magnus H. Rønne who collaborated to conduct the experimental work at Aarhus University, published in Journal of the American Chemical Society. (Photo: private)

2020.03.06 | iNano

Controlling the conversion of CO2 with new catalysts

Converting CO2 into more useful products offers an interesting strategy to mitigate climate issues while producing value added chemicals. Researchers from the Carbon Dioxide Activation Center (CADIAC) have discovered how the ligand scaffold around a manganese catalyst can be modified to control the selectivity of the products generated via…

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