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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Professor Jørgen Kjems leads the group of AU researchers participating in the project. Photo: Peter F. Gammelby

2020.03.19 | iNano

AU steps up the virus research with millions from the Carlsberg Foundation

Professor Jørgen Kjems from MBG and iNANO will collaborate with researchers from Health, the University of Copenhagen and the Danish Serum Institute, and with DKK 25 millions from the Carlsberg Foundation they will develop methods for diagnosis, treatment and prevention of SARS-CoV-2 infections. The goal is at the same time to equip the world to…

Associate Professor Alexander Zelikin is participating in EU project against corona virus. Photo: Lars Kruse, AU Photo

2020.03.19 | iNano

iNANO researcher involved in EU project against corona virus

Alexander Zelikin from iNANO and Department of Chemistry is key partner in the Fight-nCov project for developing antiviral treatment against corona virus.

From AU, researchers from the three faculties of Natural Sciences, Technical Sciences and Health participate in the ODIN network. Photo: Jesper Rais, AU Communication

2020.03.11 | iNano

Aarhus University and the pharmaceutical industry work together on open innovation - a shortcut to new medicines

Aarhus University and a number of international pharmaceutical manufacturers are joining forces in a groundbreaking, open research collaboration, ODIN (Open Discovery Innovation Network), which the Novo Nordisk Foundation supports with DKK 54.5 million. Data and results from the collaboration are made open and free to the outside world. The…

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