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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Troels Skrydstrup and his research team find a way to recycle polyurethane, a much-used plastic material which usually is very difficult to break down. (Illustration: JACS Au 1, 4, 517-524 (2021))

2021.05.28 | iNano

Newly found way to recycle polyurethane, a ubiquitous though complicated plastic material

Polyurethane (PU) is a plastic material used in an infinite number of products. Unfortunately, it is difficult to break down and recycle, which leads to increasing PU waste accumulating every year. However, researchers from Aarhus University have found a way to deconstruct PU, which shows the potential for a circular plastic economy for PU.

Steen Uttrup Pedersen and Kim Daasbjerg are cofounders of RadiSurf, a spin-out from Department of Chemistry and Interdisciplinary Nanoscience Center (iNANO) which has been acquired for triple-digit million amount. (Photo: Lars Kruse, AU Photo)

2021.05.19 | iNano

Spin-out tech-company from Aarhus University acquired for triple-digit million amount

An investment fund have acquired and invested over DKK 100 million in the tech-company, RadiSurf, a spin-out from Department of Chemistry and iNANO. This will make it possible to scale the production to supply world’s largest industries.

Skrydstrup Group at iNANO & Dept. of Chemistry (AU) participate in new partnership with industry in creating fully recyclable wind turbines. Illustration: Colourbox

2021.05.17 | iNano

New coalition of industry and academia to commercialise solution for full recyclability of wind turbine blades

A new partnership between Skrydstrup Group (iNANO & Dept. of Chemistry, Aarhus University), Vestas, Olin, and the Danish Technological Institute collides industry and research to support circularity of wind turbine blades. The CETEC project paves the way for manufacturing new blades using materials from old turbine blades, thereby creating fully…

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