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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

News

Mogens Christensen (left) is conducting research to develop more efficient and sustainable magnets. Among those he is working with is Peter Kjeldsteen (right), head of development at the company Sintex. The black rings in the picture are magnets for electric motors. Photo: Dorthe Lundh

2020.02.06 | iNano

From minus to plus – new magnet technology enhances green power

There are magnets in virtually all modern electrical equipment. However, the current versions are often based on metals with heavy impacts on the environment. Associate Professor Mogens Christensen is researching a new and cleaner magnet technology; research which also opens up for new opportunities to exploit and store electricity.

13 iNANO associated researchers have been granted DKK 8 million from the Carlsberg Foundation for research infrastructure.

2020.01.20 | iNano

DKK 8 million for research infrastructure

13 iNANO associated researchers have been granted DKK 8 million from the Carlsberg Foundation for research infrastructure

Henrik Birkedal, Merete Bilde, Tobias Weidner, Thomas Boesen, Rikke Louise Meyer, and Alexander Zelikin receive DKK 36 million in total from the Novo Nordisk Foundation for infrastructure, studies in microbial aerosols, and the battle against antimicrobial resistance. (Photos: Lars Kruse, Jesper Rais, and Lise Balsby AU Photo)

2019.12.20 | iNano

The Novo Nordisk Foundation grants DKK 36 M for iNANO researchers

Henrik Birkedal, Merete Bilde, Tobias Weidner, Thomas Boesen, Rikke Louise Meyer, and Alexander Zelikin receive DKK 36 million in total from the Novo Nordisk Foundation for infrastructure for studying bone structure, studies in microbial aerosols, and the battle against antimicrobial resistance.

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