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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  


Results published by AU researchers reveal that surfactant-mediated unfolding and refolding of proteins are complex processes with several structures present, and rearrangements occur on time scales from sub-milliseconds to minutes. (Image: Reproduced with permission from the Royal Society of Chemistry).
PhD Jannik Pedersen, PhD Jeppe Lyngsø, Professor Jan Skov Pedersen, Professor Daniel E. Otzen have published a new study in the renowned journal, Chemical Science on understanding how surfactant and protein cooperate in the process of unfolding and refolding of proteins. (Photo: Maria Randima and Jesper Rais, AU Photo)

2020.02.07 | iNano

Caught soap-handed: Understanding how soap molecules help proteins get in and out of shape

Controlling protein structure is crucial in the production of detergents and cosmetics. Up to now we have not had a clear understanding of how soap molecules and proteins work together to change protein structure. Now AU researchers have succeeded in creating a detailed picture of both unfolding and refolding of a protein by soap molecules on the…

Mogens Christensen (left) is conducting research to develop more efficient and sustainable magnets. Among those he is working with is Peter Kjeldsteen (right), head of development at the company Sintex. The black rings in the picture are magnets for electric motors. Photo: Dorthe Lundh

2020.02.06 | iNano

From minus to plus – new magnet technology enhances green power

There are magnets in virtually all modern electrical equipment. However, the current versions are often based on metals with heavy impacts on the environment. Associate Professor Mogens Christensen is researching a new and cleaner magnet technology; research which also opens up for new opportunities to exploit and store electricity.

13 iNANO associated researchers have been granted DKK 8 million from the Carlsberg Foundation for research infrastructure.

2020.01.20 | iNano

DKK 8 million for research infrastructure

13 iNANO associated researchers have been granted DKK 8 million from the Carlsberg Foundation for research infrastructure

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