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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

Jeppe V. Lauritsen receives funding for synthetic fuel production research

- Research News

The Danish Council of Independent Research has granted funds to carry out Atomic-scale studies of iron-based Fischer-Tropsch catalyst. …

iNANO and Shanghai researchers improve photoelectrocatalysis of water oxidation

- iNano

A large part of total world energy consumption is derived from non-renewable fossil fuels. Replacing this source of energy by solar energy via…

Frans Mulder receives grant from Danish Innovation Fund

- iNano

Danish Barley to secure world-class beer

Better knowledge about genetics and metabolites should provide a leading edge to Danish malting barley on…

Recent publications

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