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Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

2014 Grundfos Prize Awarded to Bo Brummerstedt Iversen

- Awards

Ground-breaking research within materials for energy optimization

 

iNANO Scientists Publish in Angewandte Chemie International Edition

- Research News

The application of transition metal catalysis in organic synthesis has revolutionized the art of contemporary synthetic organic chemistry in both…

Infrared laser light can detect poor food quality and cancer

- Research news

Danish scientists from DTU and Aarhus University have developed a new type of optical fiber that can transport light with longer wavelengths than ever…

Recent publications

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