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Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

Read more here



- Research news

Amyloid formation of proteins and peptides play a crucial role in many diseases such as Alzheimer’s, Diabetes and Parkinson’s disease. This makes…

Prof. Daniel Otzen publishes in Nature Communications

- Research news

Prof. Daniel Otzen (who recently received the Eliteforsk award) is part of an international research group that recently has uncovered one of the key…

Victoria Birkedal to host meeting at the first day of the Biophysical Society annual meeting

- People

The meeting on Nanoscale biophysics is to be held Saturday, February 15, 2014
San Francisco, California.

Find the program here.

Recent publications

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