Aarhus Universitets segl

Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

Kurt Gothelf new Member of the Royal Danish Academy of Sciences and Letters

- People

The Royal Danish Academy of Sciences and Letters admits new members every year. The new members are selected by the sitting members.

In 2014 the…

Rikke Louise Meyer and Kim Daasbjerg new members of ATV

- People

40 prominent persons from business and academia have been accepted to the Danish Academy of Technical Sciences (ATV).

Among them were associate…

Recent publications

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