Aarhus Universitets segl

Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset

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Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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News

New drug design may be a step towards developing long-awaited immunotherapy against prostate cancer

Albumin-fused T-cell engagers as a potential immunotherapy tailored to selected prostate cancer patients. iNANO, Aarhus University.

Despite numerous trials in the past decade prostate tumors have so far resisted treatment with immunotherapy. Now iNANO and Aarhus University Hospital researchers join forces to move prostate cancer immunotherapies closer to the clinic by using Albumin-fused T-cell engagers as a potential immunotherapy tailored to selected prostate cancer patients.

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