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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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New chemistry can extract virgin-grade materials from wind turbine blades in one process

After six days of catalysis in the laboratory, a piece of wind turbine blade was dissolved into intact glass fibers and bisphenol A, which can be used in the production of new blades – in addition to a fraction of various oligomers, which cannot be recycled. The metal piece was cast into the wing as part of the wind turbine's lightning protection. Photo: Alexander Ahrens, AU

Researchers from Aarhus University and the Danish Technological Institute have developed a chemical process that can disassemble the epoxy composite…

Danish-funded research to improve access to clean drinking water worldwide

- iNano

Billions of people around the world lack access to clean drinking water, leading to serious health consequences. BE-SALT, a new Danish consortium…

Professor Appointments: Brigitte Städler and Rikke Louise Meyer

Brigitte Städler and Rikke Louise Meyer have been appointed Professors in bionanoscience at iNANO, Aarhus University. (Photos by Aarhus University)

Congratulations to Brigitte Städler and Rikke Louise Meyer who have been appointed professors in bionanoscience at the Interdisciplinary Nanoscience…

Recent publications

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