Aarhus Universitets segl

Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

Read more here


Folding the code of life: Triplex origami opens new avenues of research

Figure 1: Researchers from Aarhus University have discovered a new method for constructing and studying the packaging of DNA. Illustr. Colourbox

Researchers from Aarhus University have developed a revolutionary new method, called triplex origami, to manipulate the shape and tight packing of…

Tiny nanopores can contribute to faster identification of diseases

Jørgen Kjems and collaborators have achieved a remarkable breakthrough in developing tiny nano-sized pores that can contribute to better possibilities for, among other things, detecting diseases at an earlier stage. Illustr. ACS Nano 2023, 17, 10, 9167-9177

Researchers from Aarhus University are behind a new method for detecting important proteins in, for example, a blood sample. By using tiny nanopores…

New research centre: RNA medicine for better treatment of metabolic diseases

Professor Jørgen Kjems is heading a new research centre that receives DKK 60 million from the Novo Nordisk Foundation. The funds will be used to develop new types of RNA drugs and methods to deliver them to diseased cells. Photo: Lars Kruse, AU Foto and Colourbox.

A new team of researchers dreams of making a difference for patients with e.g. diabetes, fatty liver, renal fibrosis, and atherosclerosis. With DKK 60…

Recent publications

Sortér efter: Dato | Forfatter | Titel