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Protein Biophysics (Prof. Daniel Otzen)

Daniel Erik Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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Funding for research in chronic inflammatory skin conditions and neurodegenerative diseases

Independent Research Fund Denmark - logo

Congratulations to Professor Brigitte Städler and Professor Daniel Otzen who each receive funding from Independent Research Fund Denmark. Städler and…

Award to AU-partnered project for recycling wind turbine blades

Aarhus University is a partner in the CETEC project, which receives Plastprisen 2023. On behalf of the CETEC project, Søren Haack, Project Manager at CETEC-partner Danish Technological Institute, was presented the award at Plastindustrien’s anniversary on 25 May. Photo: Plastindustrien

Partners at Aarhus University, the Danish Technological Institute, Olin, and Vestas have received Plastprisen 2023 at Plastindustrien’s anniversary on…

Recent publications

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