RSS feedhttps://inano.au.dk/Interdisciplinary Nanoscience Center (iNANO) is an internationally leading nanoscience center based at Aarhus University. Through excellent research, education and innovation, iNANO wishes to contribute to solving the Grand Challenges of our time.en-gbThu, 28 Mar 2024 09:09:18 +0100Thu, 28 Mar 2024 09:09:18 +0100TYPO3 EXT:newsnews-10114Wed, 03 Apr 2024 13:00:00 +0200PhD defence: Micropatterning and Protein Crystals as tools to investigate Cell Mechanobiologyhttps://phd.nat.au.dk/about-us/currently/nyhed/artikel/micropatterning-and-protein-crystals-as-tools-to-investigate-cell-mechanobiologyPhD student Anne-Kathrine Kure Larsen, iNANOExamPhD activitiesLise Refstrup Linnebjerg PedersenWed, 03 Apr 2024 13:00:00 +0200Wed, 03 Apr 2024 15:00:00 +0200Building 1531, room 119, Lecture Theatre Aud-D2, Department of Mathematics, Aarhus University, Ny Munkegade 118, 8000 Aarhus CBuilding 1531, room 119, Lecture Theatre Aud-D2, Department of Mathematics, Aarhus University, Ny Munkegade 118, 8000 Aarhus C1712142000171214920017121420001712149200news-10104Thu, 04 Apr 2024 13:15:00 +0200PhD defence: Aqueous carbonation of cement pastes – towards a sustainable and circular utilization of end-of-life concretehttps://phd.nat.au.dk/about-us/currently/nyhed/artikel/aqueous-carbonation-of-cement-pastes-towards-a-sustainable-and-circular-utilization-of-end-of-life-concretePhD student Fabio Mariz Maia Neto, iNANOExamPhD activitiesLise Refstrup Linnebjerg PedersenThu, 04 Apr 2024 13:15:00 +0200Thu, 04 Apr 2024 15:15:00 +0200Building 1514, room 213, Auditorium I, Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus CBuilding 1514, room 213, Auditorium I, Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C1712229300171223650017122293001712236500news-10054Fri, 05 Apr 2024 10:15:00 +0200Distinguished iNANO lecture by Professor Ruibing Wang, Department of Pharmaceutical Sciences, University of Macauhttps://inano.au.dk/about/news-events/news/show/artikel/distinguished-inano-lecture-by-professor-ruibing-wang-department-of-pharmaceutical-sciences-university-of-macauSupramolecularly Engineered Cells for Targeted Therapy Professor Ruibing Wang, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences & Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macau SAR

Supramolecularly Engineered Cells for Targeted Therapy

Cells are a basic unit of living organisms and using them as drug carriers or therapeutics has unique advantages. During the past several years, we have developed a unique “supramolecular cell engineering” approach where nanomedicines or biomaterials are self-assembled either extracellularly or intracellularly via artificial host-guest interactions, to anchor nanomedicine or biomaterials either on the surface of, or inside, the cells for targeted delivery to specific tissues, e.g. driven by the inflammatory tropism of immune cells.1 We show that the engineered cells may efficiently deliver medicine to disease tissues and effectively treat several diseases including acute pneumonia2 and solid tumors.3 We also show that intracellularly gelated macrophage may function as “cell sponge” to absorb inflammatory cytokines, endotoxins and even bacteria, to effectively fight against infectious diseases.4,5


References
[1] Wang, R. et al, Nat. Commun. 2020, 11: 2622.
[2] Wang, R. et al, Adv. Mater. 2023, 35: 202211626.
[3] Wang, R. et al, Sci. Adv. 2022, 8: eabn1805. 
[4] Wang, R. et al, Matter, 2023, 6: 3889.
[5] Wang, R. et al, Nat. Commun. 2024, 15: 328.


Author’s BIOGRAPHY
Dr. Ruibing Wang is currently Professor of Supramolecular Pharmaceutics at University of Macau. He obtained his BSc and PhD degrees from Jilin University and Queen’s University, Canada, respectively, and has become an elected Fellow, the Royal Society of Chemistry since 2020. Prof. Wang’s research interest is supramolecular biomaterials, and cell-mimetic and cell-based pharmaceutics. He has published over 200 peer-reviewed research papers on Nature Commun., Sci. Adv., Matter, JACS, Angew, Adv. Mater., Mater. Today etc, with a total citation of over 10,000 times and H-index of 57. He has won several prestigious awards including 2018 Macao Science and Technology Award - Natural Science Award, 2019 UM Teaching Excellence Award, 2020 Macau Science and Technology Award - Technological Invention Award, and 2022 Macau Science and Technology Award – Natural Science Award.  He is among the list of Stanford’s World's Top 2% Scientists. He actively serves in the editorial boards of Chin. Chem. Lett., Supramol. Mater., and ACS App. Bio Mater., he is also a council member of Supramolecular Chemistry Advisory Committee of Chinese Chemical Society.

 

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Distinguished iNANO LecturesiNanoTrine Møller HansenFri, 05 Apr 2024 10:15:00 +0200Fri, 05 Apr 2024 11:00:00 +0200iNANO AUD (1593-012)iNANO AUD (1593-012)1712304900171230760017123049001712307600
news-10056Fri, 05 Apr 2024 13:15:00 +0200PhD defence: 3D printing of soft robotics and semi-synthetic tissuehttps://phd.nat.au.dk/about-us/currently/nyhed/artikel/3d-printing-of-soft-robotics-and-semi-synthetic-tissue-1PhD student Stefan Pendlmayr, iNANOExamPhD activitiesLise Refstrup Linnebjerg PedersenFri, 05 Apr 2024 13:15:00 +0200Fri, 05 Apr 2024 15:15:00 +0200Building 1593, room 012, Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus CBuilding 1593, room 012, Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C1712315700171232290017123157001712322900news-10112Fri, 05 Apr 2024 13:15:00 +0200Qualifying exam: Bone Remodeling in Health and Disease: Multiscale Mapping of Mineral, Matrix, and Microarchitecturehttps://phd.nat.au.dk/about-us/currently/show-events/artikel/qualifying-exam-bone-remodeling-in-health-and-disease-multiscale-mapping-of-mineral-matrix-and-microarchitecturePhD Student Anastasiia Sadetskaia, iNANOExamPhD activitiesLise Refstrup Linnebjerg PedersenFri, 05 Apr 2024 13:15:00 +0200Fri, 05 Apr 2024 15:15:00 +02001593-218, iNANO, Aarhus University, Gustav Wieds Vej 22, 8000 Aarhus C1593-218, iNANO, Aarhus University, Gustav Wieds Vej 22, 8000 Aarhus C1712315700171232290017123157001712322900news-10088Tue, 09 Apr 2024 13:00:00 +0200Qualifying exam: Chemical Zymogens in Synthetic Cells for on-demand transmembrane activation of transcriptionhttps://phd.nat.au.dk/about-us/currently/show-events/artikel/qualifying-exam-chemical-zymogens-in-synthetic-cells-for-on-demand-transmembrane-activation-of-transcriptionPhD Student Dante Guldbrandsen Andersen, iNANOExamPhD activitiesLise Refstrup Linnebjerg PedersenTue, 09 Apr 2024 13:00:00 +0200Tue, 09 Apr 2024 15:00:00 +02001590-213, iNANO, Gustav Wieds Vej 14, 8000 Aarhus C1590-213, iNANO, Gustav Wieds Vej 14, 8000 Aarhus C1712660400171266760017126604001712667600news-9714Wed, 14 Aug 2024 08:00:00 +0200ArtBio 2024https://events.au.dk/artbio2024/conferenceArtBio2024: 2nd Artificial Biology Conference: Assemble – Imitate - AdaptDistinguished iNANO LecturesiNanoNano MaterialsTrine Møller HansenWed, 14 Aug 2024 08:00:00 +0200Fri, 16 Aug 2024 18:00:00 +0200iNANO, Gustav Wieds Vej 14, 8000 Aarhus CiNANO, Gustav Wieds Vej 14, 8000 Aarhus C1723615200172382400017236152001723824000