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Distinguished iNANO lecture: Biomimetic polymersomes: From active biomaterials to protocells

Professor Sébastien Lecommandoux, Laboratoire de Chimie des Polymères Organiques (LCPO), Université de Bordeaux, France

2019.05.20 | Trine Møller Hansen

Date Fri 24 May
Time 10:15 11:00
Location iNANO Auditorium (1593-012), Gustav Wieds Vej 14, 8000 Aarhus C

Professor Sébastien Lecommandoux, Laboratoire de Chimie des Polymères Organiques (LCPO), Université de Bordeaux, France

Biomimetc polymersomes: From active biomaterials to protocells

 

We report here an overview on the self-assembly of amphiphilic block copolymers developed at LCPO into different nanomedicines, mainly focusing on polymer vesicles, also referred as polymersomes, and their applications in loading and controlled release of both hydrophilic and hydrophobic molecules and biomolecules.

We pay special attention to polysaccharide and polypeptide-based block copolymer vesicles and their development in nanomedicine.[1-3] In this context, we developed over the last years synthetic strategies for the design of glycosylated polypeptides and polysaccharide-polypeptide biohybrids with controlled placement of sugar functionality. We were especially interested in designing amphiphilic copolymers able to self-assemble into well- defined micelles and vesicles that can advantageously be loaded with drugs and present a surface with multivalent presentation of bioactive saccharides or oligosaccharides. The ability of these nanoparticles for different biomedical applications, from drug-delivery to inhibitor, will be presented. We especially evidenced the particular benefit of nanoparticles and their multivalency toward the interaction with biological receptors.[4-5] In order to get closer to the real structure of glycoproteins, we are now moving from synthetic to genetically engineered polypeptides, focusing on post-modification of elastin-like proteins. [6-7]

Finally, our recent advances in using “biomimicry approaches” to design complex, compartmentalized and functional protocells will be proposed. Such a system constitutes a first step towards the challenge of structural cell mimicry and functionality, and may act in the future as an autonomous artificial cell that can sense and cure in situ any biological deregulation..[8-12]

 

REFERENCES:

1.       C. Bonduelle, S. Lecommandoux. Biomacromolecules 2013, 14, 2976-2983
2.       Jeannot, V. et al. Nanomedicine: Nanotechnology, Biology, and Medicine 2016, 4, 921
3.       V. Jeannot, et al. J. Control. Release 2018, 275, 117-128
4.       C. Bonduelle et al. Chem. Commun. 2014, 50, 3350
5.       H. Duan et al. Scientific Report 2018, 8:14730
6.       J.R. Kramer et al. ACS Macro Letters 2015 4, 1283-1286
7.       R. Petitdemange et al. Bioconjugate chemistry 2017 28, 1403-1412
8.       M. Marguet et al. Angew. Chem. Int. Ed. 2012, 51, 1173
9.       R. J. R. W. Peters et al. Angew. Chem. Int. Ed. 2014, 53, 146-150
10.    A. Peyret et al. Angew. Chem. Int. Ed. 2017, 56, 1566-1570
11.    A Peyret et al. Advanced Sciences 2018, 5, 1700453
12.    A Peyret et al. Langmuir 2018, 34,3376.


Host:
Associate professor Birgitte Städler, iNANO & Dept. of Chemistry, Aarhus University


Coffe, tea, and bread will be served from 10:00 am in front of iNANO AUD.

Distinguished iNANO Lectures