Bioengineered Drug Designs Laboratory (Ken Howard)

The focus of the lab is protein engineered solutions to the delivery requirements of biomacromolecules that considers both the drug and carrier, with albumin the predominant drug delivery platform. The natural transport properties and an ability to tune the pharmacokinetics with recombinant variants of albumin provides the perfect scaffold for biomolecular drug assemblies. A key component is the application of nucleic acid nanotechnology to allow site-selective multifunctionalisation with a range of bioactive or imaging moieties with precise control over moiety number and display pattern; a focus of the Center for Multifunctional Biomolecular Drug Designs (CEMBID) to which the lab is associated.