Martirosyan, A., Olesen, M. J., Fenton, R. A., Kjems, J. & Howard, K. A. (2016).
Mucin-mediated nanocarrier disassembly for triggered uptake of oligonucleotides as a delivery strategy for the potential treatment of mucosal tumours.
Nanoscale,
8(25), 12599-12607.
https://doi.org/10.1039/c5nr07206a
Ostenfeld, M. S., Jeppesen, D. K., Bramsen, J. B., Laurberg, J. R., Howard, K., Dyrskjøt, L. & Ørntoft, T. F. (2015).
Selective cellular removal of miR23b by Rab27a/b-dependent exosome release is linked to acquisition of a metastatic property in bladder cancer. Cancer Research.
Whitehead, B. J., Wu, L.
, Hvam, M. L., Aslan, H., Dong, M., Dyrskjøt, L., Ostenfeld, M. S., Moein Moghimi, S.
& Howard, K. (2015).
Tumour exosomes display different differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness.
Journal of Extracellular Vesicles,
4, Article 29685.
https://doi.org/10.3402/jev.v4.29685
Ebbesen, M. F., Olesen, M. T. J., Gjelstrup, M. C., Pakula, M. M., Larsen, E. K., Hansen, I. M., Hansen, P. L., Mollenhauer, J., Malle, B. M.
& Howard, K. (2015).
Tunable CD44-Specific Cellular Retargeting with Hyaluronic Acid Nanoshells.
Pharmaceutical Research,
32(4), 1462-1474.
https://doi.org/10.1007/s11095-014-1552-7
Yang, H. Y., Vonk, L. A., Licht, R., Van Boxtel, A. M. G., Bekkers, J. E. J., Kragten, A. H. M.
, Hein, S., Varghese, O. P.
, Howard, K., Cumhur Öner, F., Dhert, W. J. A. & Creemers, L. B. (2014).
Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells.
European Journal of Pharmaceutical Sciences,
53(1), 35-44.
https://doi.org/10.1016/j.ejps.2013.12.006
Jeppesen, D. K., Hvam, M. L., Primdahl-Bengtson, B.
, Boysen, A. T., Whitehead, B., Dyrskjøt, L., Orntoft, T. F., Howard, K. & Ostenfeld, M. S. (2014).
Comparative analysis of discrete exosome fractions obtained by differential centrifugation.
Journal of Extracellular Vesicles,
3, 1-16. Article 25011.
https://doi.org/10.3402/jev.v3.25011
Ebbesen, M. F., Bienk, K., Deleuran, B. W. & Howard, K. (2014).
Extended circulation and accumulation of p(HPMA-co-AzMA) and accumulation in arthritic joints. Poster session presented at 41st Annual Meeting & Exposition of the Controlled Release Society, July 13-16, 2014 Chicago, USA , Chicago, United States.
Rubert, M., Fang-Li, Y.
, Aslan, H., Yu, Y.
, Howard, K. A., Dong, MD., Besenbacher, F. & Chen, M. (2014).
Inflammatory response of RAW 264.7 cells to ultraporous interweaving PCL-PEO electrospun microfibers.
Journal of Tissue Engineering and Regenerative Medicine,
8, 249-249.
Jeppesen, D. K., Nawrocki, A.
, Jensen, S. G., Thorsen, K., Whitehead, B., Howard, K., Andersen, L. D., Orntoft, T. F., Larsen, M. R.
& Ostenfeld, M. S. (2014).
Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors.
Proteomics,
14(6), 699-712.
https://doi.org/10.1002/pmic.201300452
Miclaus, T., Bochenkov, V., Ogaki, R., Howard, K. & Sutherland, D. S. (2014).
Spatial Mapping and Quantification of Soft and Hard Protein Coronas at Silver Nanocubes.
Nano Letters,
14(4), 2086-2093.
https://doi.org/10.1021/nl500277c
Whitehead, B. J., Hvam, M. L., Bienk, K., Ostenfeld, M. S. & Howard, K. (2014).
The Application of a Fluorescent Pre-Labelling Method for Evaluation of Exosome Biodistribution. Poster session presented at The 41st Annual Meeting & Exposition of the Controlled Release Society, Chicago, United States.
Li, Y. Y., Femenias, M. R., Aslan, H. H., Yu, Y. Y.
, Howard, K., Dong, MD., Besenbacher, F. F. & Chen, M. M. (2014).
Ultraporous interweaving electrospun microfibers from PCL-PEO binary blends and their inflammatory responses.
Nanoscale,
6(6), 3392-3402.
https://doi.org/10.1039/c3nr06197c
Ostenfeld, M. S., Jeppesen, D. K., Laurberg, J. R., Boysen, A., Howard, K., Christensen, E. I., Morth, P., Bui, K. H., Theodorescu, D.
, Jensen, J. B., Borre, M., Dyrskjøt, L. & Ørntoft, T. F. (2013).
Keystone Symposia "ncRNAs in Development and Cancer", Vancouver, Canada: Increased release of exosomes and export of invasion-modulating miRNAs miR921, -23b, -and -224 from metastatic urothelial carcinoma cells.
Nawroth, I., Alsner, J., Deleuran, B. W., Dagnæs-Hansen, F., Yang, C., Horsman, M. R., Overgaard, J., Howard, K., Kjems, J. & Gao, S. (2013).
Peritoneal macrophages mediated delivery of chitosan/siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model.
Acta Oncologica,
52(8), 1730-1738.
https://doi.org/10.3109/0284186X.2012.726373
Gonzalez, B. B., Dagnæs-Hansen, F., Fenton, R. A., Gao, S., Hein, S., Dong, M., Kjems, J. & Howard, K. A. (2013).
Protection and systemic translocation of siRNA following oral administration of chitosan/siRNA nanoparticles.
Molecular Therapy - Nucleic Acids,
2(1), 1-8. Article e76.
https://doi.org/10.1038/mtna.2013.2
Ebbesen, M. F., Whitehead, B. J., Gonzalez, B. B., Kingshott, P.
& Howard, K. (2013).
Surface analysis of PEGylated nano-shields on nanoparticles installed by hydrophobic anchors.
Pharmaceutical Research,
30(7), 1758-1767.
https://doi.org/10.1007/s11095-013-1018-3
Ebbesen, M. F., Schaffert, D. H., Crowley, M. L., Oupický, D.
& Howard, K. (2013).
Synthesis of click-reactive HPMA copolymers using RAFT polymerization for drug delivery applications.
Journal of Polymer Science. Part A, Polymer Chemistry,
51(23), 5091-5099.
https://doi.org/10.1002/pola.26941
Larsen, E. K. U., Nielsen, T., Wittenborn, T., Rydtoft, L. M., Lokanathan, A. R., Hansen, L., Østergaard, L., Kingshott, P., Howard, K. A., Besenbacher, F., Nielsen, N. C. & Kjems, J. (2012).
Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors.
Nanoscale,
4(7), 2352-2361 .
https://doi.org/10.1039/C2NR11554A
Chen, M., Gao, S., Dong, M., Song, J., Yang, C., Howard, K. A., Kjems, J. & Besenbacher, F. (2012).
Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery.
A C S Nano,
6(6), 4835-4844.
https://doi.org/10.1021/nn300106t
de Paz, L.
, Resin, A., Howard, K., Sutherland, D. S. & Wejse, P. (2011).
Antimicrobial effect of chitosan nanoparticles on streptococcus mutans biofilms.
Applied and Environmental Microbiology,
77(11), 3892-3895.
Rahbek, U. L., Nielsen, A. F., Dong, M., You, Y., Chauchereau, A., Oupicky, D.
, Besenbacher, F., Kjems, J. & Howard, K. A. (2010).
Bioresponsive hyperbranched polymers for siRNA and miRNA delivery.
Journal of Drug Targeting,
18(10), 812-20.
https://doi.org/10.3109/1061186X.2010.527982
Mittnacht, U., Hartmann, H.
, Hein, S., Oliveira, H.
, Dong, M., Pêgo, A. P.
, Kjems, J., Howard, K. A. & Schlosshauer, B. (2010).
Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth.
Nano Letters,
10(10), 3933-9.
https://doi.org/10.1021/nl1016909
Nawroth, I., Alsner, J., Behlke, M. A.
, Besenbacher, F., Overgaard, J., Howard, K. A. & Kjems, J. (2010).
Intraperitoneal administration of chitosan/DsiRNA nanoparticles targeting TNFα prevents radiation-induced fibrosis.
Radiotherapy & Oncology,
97(1), 143-8.
https://doi.org/10.1016/j.radonc.2010.09.010
Nielsen, E. J. B., Nielsen, J. M., Becker, D., Karlas, A., Prakash, H.
, Glud, S. Z., Merrison, J., Besenbacher, F., Meyer, T. F.
, Kjems, J. & Howard, K. A. (2010).
Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles.
Pharmaceutical Research,
27(12), 2520-7.
https://doi.org/10.1007/s11095-010-0255-y
Andersen, M. Ø., Nygaard, J. V., Burns, J. S.
, Raarup, M. K., Nyengaard, J. R., Bünger, C., Besenbacher, F., Howard, K. A., Kassem, M. & Kjems, J. (2010).
siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells.
Molecular Therapy,
18(11), 2018-2027.
https://doi.org/10.1038/mt.2010.166
Kjems, J., Overgaard, J., Howard, K., Alsner, J., Besenbacher, F. & Nawroth, I. (2010).
Treatment of radiation-induced fibrosis. (Patent No.
WO2010085959A1).
Hartmann, H., Lakner, U.
, Andersen, M. Ø., Kjems, J., Howard, K. A. & Schloßhauer, B. (2009).
Carrier Matrix for siRNA-Mediated Gene Knock Down to Promote Neuronal Regeneration. Tissue Engineering. Part A. Tissue Engineering, (3), 718.
Mistry, A.
, Glud, S. Z., Kjems, J., Nyengaard, J. R., Howard, K. A., Stolnik, S. & Illum, L. (2009).
Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium.
Journal of Drug Evaluation,
17(7), 543-552.
https://doi.org/10.1080/10611860903055470
Glud, S. Z., Bramsen, J. B., Dagnaes-Hansen, F., Wengel, J.
, Howard, K. A., Nyengaard, J. R. & Kjems, J. (2009).
Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration.
Oligonucleotides,
19(2), 163-8.
https://doi.org/10.1089/oli.2008.0175
Larsen, E. K. U., Nielsen, T., Wittenborn, T., Birkedal, H., Vorup-Jensen, T., Jakobsen, M. H.
, Østergaard, L., Horsman, M. R., Besenbacher, F., Howard, K. A. & Kjems, J. (2009).
Size-Dependent Accumulation of PEGylated Silane-Coated Magnetic Iron Oxide Nanoparticles in Murine Tumors.
A C S Nano,
3(7), 1947-51.
https://doi.org/10.1021/nn900330m
Gao, S., Dagnæs-Hansen, F., Nielsen, E. J. B., Wengel, J.
, Besenbacher, F., Howard, K. A. & Kjems, J. (2009).
The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.
Molecular Therapy,
17(7), 1225-1233.
https://doi.org/10.1038/mt.2009.91
Howard, K. A., Paludan, S. R., Behlke, M. A.
, Besenbacher, F., Deleuran, B. W. & Kjems, J. (2008).
Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model.
Molecular Therapy,
17(1), 162-168.
https://doi.org/10.1038/mt.2008.220
Andersen, M. Ø., Howard, K. A., Paludan, S. R., Besenbacher, F. & Kjems, J. (2008).
Delivery of siRNA from lyophilized polymeric surfaces.
Biomaterials,
29(4), 506-512.
https://doi.org/10.1016/j.biomaterials.2007.10.003
Rahbek, U. L., Howard, K. A., Oupicky, D., Manickam, D. S.
, Dong, M., Nielsen, A. F., Hansen, T. B., Besenbacher, F. & Kjems, J. (2008).
Intracellular siRNA and precursor miRNA trafficking using bioresponsive copolypeptides.
Journal of Gene Medicine,
10(1), 81-93.
https://doi.org/10.1002/jgm.1120
Nygaard, J. V., Andersen, M. Ø., Howard, K. A., Foss, M., Bünger, C., Kjems, J. & Besenbacher, F. (2008).
Investigation of particle-functionalized tissue engineering scaffolds using X-ray tomographic microscopy.
Biotechnology and Bioengineering (Print),
100(4), 820-9.
https://doi.org/10.1002/bit.21796