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Protein Biophysics (Prof. Daniel Otzen)

Daniel Otzen

Professor Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset


Group members
Research funding

Research focus in brief

Our research activities fall within 3 main areas, which all relate to the study of the kinetics and thermodynamics of protein conformational changes, namely membrane protein folding, protein-detergent interactions and protein fibrillation. These areas are linked by a keen interest in understanding the mechanistic and thermodynamic behaviour of proteins in different circumstances by quantifying the strength of internal side-chain interactions as well as contacts with solvent molecules, whether it be detergents, denaturants, stabilizing salts and osmolytes or lipids. Ultimately we hope this will lead to a greater manipulative ability vis-a-vis processes of both basic, pharmaceutical and industrial relevance. The general approach is to use available spectroscopic techniques (fluorescence, CD, stopped-flow, FTIR, NMR and dynamic and static light scattering) to generate data which can be analyzed in a quantitative manner to develop models and mechanisms for conformational changes at the molecular level.  

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New chemical methods by the Gothelf Lab with potential for drug delivery

Method for automated solid-phase oligo(disulfide) published in Angewandte Chemie by the Gothelf Lab.

Traditional medicines typically work by targeting the body in a non-specific way, which can lead to unnecessary side effects and the need for taking…

Entrepreneurs from iNANO receive DKK 12m to revolutionise stroke treatment

MedicQuant is a spin-out from iNANO & Dept. of Chemistry founded in 2019 by CEO and PhD Line Debois, CTO and PhD Malthe Hansen-Bruhn, and Professor Kurt Gothelf. Photo: MedicQuant / PR

The spin-out company, MedicQuant, from Aarhus University raises more than DKK 12 million in capital to further develop a rapid analysis tool that will…

Recent publications

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